====== Transgenic expression ====== in Drosophila unless indicated otherwise O: (other). Transgenic overexpression in the same organism is indicated as (OE). Result is lower toxicity or metabolism of the listed chemical(s) unless indicated otherwise (i.e. bioactivation leading to higher toxicity). |^CYP^species^transgenic expression^reference^ ^[[cyp_clans|CYP2 clan]]|||| ^CYP15C1|Bombyx mori|O:(Bombyx) rescues mod mutation |Daimon et al., 2012| ^CYP303A1|Drosophila melanogaster|rescues null mutations |Wu et al., 2019| ^CYP304A1|Aedes albopictus|haedoxan A|Pei et al., 2022| ^CYP392A11|Tetranychus urticae|fenproximate|Riga et al., 2015| ^CYP392A16|Tetranychus urticae|abamectin|Riga et al., 2014; 2020| ^CYP392D8|Tetranychus urticae|no effect on abamectin toxicity|Xu et al., 2023| ^[[cyp_clans|CYP3 clan]]|||| ^CYP6A36|Musca domestica|permethrin|Li et al. 2023| ^CYP6A51|Ceratitis capitata|λ-cyhalothrin, deltamethrin|Tsakireli et al. 2019| ^CYP6D1|Musca domestica|benzo[a]pyrene|Korytko et al., 2000| ^CYP6D10|Musca domestica|permethrin|Li et al., 2023| ^CYP6G1|Drosophila melanogaster|(OE)DDT|Daborn et al. 2002, Daborn et al., 2007| ^CYP6G1|Drosophila melanogaster|(OE)DDT, dicyclanil, nitenpyram|Daborn et al., 2007, Chung et al. 2007| ^CYP6G1|Drosophila melanogaster|(OE)azinphos-methyl|Battlay et al. 2016| ^CYP6G1|Drosophila melanogaster|(OE)imidacloprid|Denecke et al. 2017| ^CYP6G1|Drosophila melanogaster|(OE)bendiocarb, imidacloprid, malathion|Luong et al., 2022| ^CYP6G2|Drosophila melanogaster|(OE)nitenpyram, diazinon|Daborn et al. 2007| ^CYP6G2|Drosophila melanogaster|(OE)imidacloprid|Denecke et al. 2017| ^CYP6G4|Musca domestica |propoxur|Zhu et al., 2022| ^CYP6G4 wt & mut|Musca domestica |propoxur|You et al., 2023| ^CYP6G4|Musca domestica |chlorpyrifos, tetramethrin, methomyl, acetamiprid, imidacloprid, NOT permethrin |Zhu et al., 2023| ^CYP6M2|Anopheles gambiae|pyrethroids, DDT, bendiocarb|Stevenson et al., 2011 Mitchell et al., 2012 Edi et al., 2014| ^CYP6M2|Anopheles gambiae|O:(A.gambiae) pyrethroids, malathion(activation)|Adolfi et al. 2019| ^CYP6M7|Anopheles funestus|pyrethroids|Riveron et al.,2014| ^CYP6P3|Anopheles gambiae|pyrethroids, bendiocarb |Muller et al., 2008 Edi et al., 2014| ^CYP6P3|Anopheles gambiae|O:(A.gambiae) pyrethroids|Adolfi et al. 2019| ^CYP6P3 (E205D allele)|Anopheles gambiae|pyrethroids, propoxur,bendiocarb, NOT DDT |Kengne-Ouafo et al., 2024| ^CYP6P4a Mwi|Anopheles funestus|permethrin, deltamethrin|Tatchou-Nebangwa et al., 2024| ^CYP6P4a Ghana|Anopheles funestus|permethrin, deltamethrin, a-cypermethrin|Tatchou-Nebangwa et al., 2024| ^CYP6P4b Ghana|Anopheles funestus|permethrin,deltamethrin,a-cypermethrin |Tatchou-Nebangwa et al., 2024| ^CYP6P4b Moz|Anopheles funestus|permethrin,deltamethrin, a-cypermethrin|Tatchou-Nebangwa et al., 2024| ^CYP6P5|Anopheles albimanus|pyrethroids|Kusimo et al. 2022| ^CYP6P9a|Anopheles funestus|pyrethroids|Riveron et al., 2013 Ibrahim et al., 2015| ^CYP6P9a|Anopheles funestus|clothianidin, chlorfenapyr (activation)|Tchouakui et al., 2024| ^CYP6P9b|Anopheles funestus|pyrethroids|Riveron et al., 2013 Ibrahim et al., 2015| ^CYP6P9b|Anopheles funestus|clothianidin, chlorfenapyr (activation)|Tchouakui et al., 2024| ^CYP6P12|Aedes albopictus|permethrin|Ishak et al. 2016| ^CYP6W1|Drosophila melanogaster|(OE) DDT|Schmidt et al. 2017| ^CYP6Z2|Anopheles coluzzi|a-cypermethrin, deltamethrin, clothianidin(higher toxicity)|Ibrahim et al., 2023| ^CYP6AA1|Anopheles funestus|pyrethroids|Ibrahim et al., 2018| ^CYP6AB12|Spodoptera litura|cyantraniliprole|Li et al., 2023| ^CYP6AB45|Chilo suppressalis|no effect on chlorantraniliprole, abamectin, triazophos, sinetoram tox.|Wang et al., 2024| ^CYP6AB58|Spodoptera litura|no effect on cyantraniliprole tox.|Li et al., 2023| ^CYP6AB59|Spodoptera litura|cyantraniliprole|Li et al., 2023| ^CYP6AE44|Spodoptera litura|abamectin|Liang et al., 2024| ^CYP6AE70|Spodoptera exigua|chlorpyrifos, cypermethrin, deltamethrin|Hu et al., 2024| ^CYP6AE178|Hyphantria cunea|cytisine, coumarin| Li et al., 2024| ^CYP6AN4|Spodoptera litura|cyantraniliprole, by feeding, not topical|Li et al., 2023| ^CYP6AQ83|Solenopsis invicta|flonicamid| Zhang et al., 2024| ^CYP6AS161(called 6A14)|Solenopsis invicta|flonicamid|Zhang et al., 2023| ^CYP6AY1|Nilaparvata lugens|imidacloprid|cited in McLeman et al., 2020| ^CYP6AY3v2|Laodelphax striatellus|imidacloprid|Wang et al. 2017| ^CYP6BG1|Plutella xylostella|chlorantraniliprole, cypermethrin, NOT abamectin|Li et al., 2017| ^CYP6BG1|Plutella xylostella|chlorantraniliprole|Mallott et al., 2019| ^CYP6BQ9|Tribolium castaneum|deltamethrin|Zhu et al., 2010| ^CYP6BQ9|Tribolium castaneum|O:(Fall armyworm) deltamethrin|Chen and Palli 2021| ^CYP6BQ23|Meligethes (Brassicogethes) aeneus|deltamethrin|Samantsidis et al., 2020| ^CYP6CM1vQ|Bemisia tabaci|imidacloprid, nitenpyram|Daborn et al., 2012| ^CYP6CM1(A387G)|Bemisia tabaci| imidacloprid, clothianidin|Pym et al., 2023a| ^CYP6CS1|Nilaparvata lugens|pymetrozine|Wang et al., 2021| ^CYP6CX3|Bemisia tabaci| cyantraniliprole|Zhang et al., 2022| ^CYP6CX4|Bemisia tabaci| flupyradifurone|Zhang et al., 2024| ^CYP6CY3|Myzus persicae nicotianae|nicotine, clothianidin|Bass et al., 2013| ^CYP6CY3|Myzus persicae nicotianae|nicotine|McLeman et al., 2020| ^CYP6CY4|Myzus persicae nicotianae|nicotine|McLeman et al., 2020| ^CYP6CY5|Aphis gossypii|cyantraniliprole|Ding et al. 2023| ^CYP6CY7|Aphis gossypii|cyantraniliprole, a-cypermethrin|Zeng et al. 2021| ^CYP6CY9|Aphis gossypii|thiamethoxam, imidacloprid|Lv et al. 2022| ^CYP6CY9|Aphis gossypii|cyantraniliprole|Ding et al. 2023| ^CYP6CY18|Aphis gossypii|imidacloprid|Lv et al. 2022| ^CYP6CY19|Aphis gossypii|cyantraniliprole|Ding et al. 2023| ^CYP6CY21|Aphis gossypii|cyantraniliprole, a-cypermethrin|Zeng et al. 2021| ^CYP6CY22|Aphis gossypii|imidacloprid|Lv et al. 2022| ^CYP6CY22|Aphis gossypii|cyantraniliprole, xanthotoxin, quercetin, 2-tridecanone,tannic acid, nicotine|Ding et al. 2024| ^CYP6CZ1|Aphis gossypii|thiamethoxam|Lv et al. 2022| ^CYP6CZ1|Aphis gossypii|cyantraniliprole|Ding et al. 2023| ^CYP6DA1|Aphis gossypii|cyantraniliprole|Ding et al. 2023| ^CYP6DB1|Aphis gossypii|thiamethoxam|Lv et al. 2022| ^CYP6DB1|Aphis gossypii|cyantraniliprole|Ding et al. 2023| ^CYP6DB3|Bemisia tabaci|imidacloprid, thiamethoxam|Wei et al., 2023| ^CYP6DD1|Aphis gossypii|cyantraniliprole|Ding et al. 2023| ^CYP6DP1|Trialeurodes vaporarium|imidacloprid,nicotine|Pym et al., 2023b| ^CYP6DP2|Trialeurodes vaporarium|imidacloprid,nicotine|Pym et al., 2023b| ^CYP6DP3|Bemisia tabaci|imidacloprid,nicotine|Pym et al., 2023b| ^CYP6DP5|Bemisia tabaci|imidacloprid,NOT nicotine|Pym et al., 2023b| ^CYP6EM1|Bemisia tabaci|dinetofuran|Huang et al., 2024| ^CYP6ER1|Nilaparvata lugens|imidacloprid|Pang et al., 2016| ^CYP6ER1|Nilaparvata lugens|imidacloprid|Zimmer et al., 2018| ^CYP6ER1vA|Nilaparvata lugens|imidacloprid,nitenpyram,cycloxaprid; NOT sulfoxaflor,triflumezopyrim,pymetrozine|Gong et al., 2023| ^CYP6FJ3|Sogatella furcifera |pymetrozine|Gong et al., 2023| ^CYP6FU1|Laodelphax striatellus|NOT fenvalerate|Yu et al., 2023| ^CYP6FV21|Bradysia odoriphaga|imidacloprid, λ-cyhalothrin |Zhang et al., 2024 | ^CYP6QE1|Bradysia odoriphaga|imidacloprid, λ-cyhalothrin|Zhang et al., 2024 | ^CYP9A32|Spodoptera litura|abamectin|Liang et al., 2024| ^CYP9A157 (called CYP9A75a)|Spodoptera litura|cyantraniliprole, a-cypermethrin, nicotine | Li et al., 2024| ^CYP9A158 (called CYP9A75b)|Spodoptera litura|cyantraniliprole, a-cypermethrin, nicotine | Li et al., 2024| ^CYP9A186(F116V)|Spodoptera exigua|O(H.armigera) emamectin benzoate,abamectin (high R)| Li et al., 2023| ^CYP9A186(F116V)|Spodoptera exigua|emamectin benzoate,abamectin (low R)| Li et al., 2023| ^CYP9A186|Spodoptera exigua|O(Plutella xylostella) emamectin benzoate, abamectin |Wang et al., 2024| ^CYP9J11|Anopheles funestus|pyrethroids|Riveron et al., 2017| ^CYP9J28|Aedes aegypti|pyrethroids|Stevenson et al., 2012; Pavlidi et al.,2012; Samantsidis et al., 2020| ^CYP9K1(G454A)|Anopheles funestus|more R than wt: deltamethrin, cypermethrin, permethrin|Djoko et al.,2025| ^CYP9Q1|Apis mellifera|thiacloprid|Manjon et al.2018| ^CYP9Q2|Apis mellifera|thiacloprid|Manjon et al.2018| ^CYP9Q2|Apis mellifera|flupyradifurone|Haas et al. 2021| ^CYP9Q2|Apis mellifera|chlorantraniliprole, NOT flubendiamide|Haas et al. 2022 | ^CYP9Q2|Apis mellifera|coumaphos, coumaphos oxon|Xiao et al. 2024 | ^CYP9Q3|Apis mellifera|thiacloprid|Manjon et al.2018| ^CYP9Q3|Apis mellifera|flupyradifurone|Haas et al. 2021| ^CYP9Q3|Apis mellifera|chlorantraniliprole, NOT flubendiamide|Haas et al. 2022 | ^CYP9Q3|Apis mellifera|coumaphos, coumaphos oxon|Xiao et al. 2024 | ^CYP9Q4|Bombus terrestris|thiacloprid|Manjon et al.2018| ^CYP9Q5|Bombus terrestris|thiacloprid|Manjon et al.2018| ^CYP9Q6|Bombus terrestris|thiacloprid, acetamiprid|Troczka et al.,2019| ^CYP9R38|Osmia bicornis|thiacloprid|Beadle et al., 2019| ^CYP9BU1|Osmia bicornis|thiacloprid, NOT imidacloprid|Beadle et al., 2019| ^CYP9BU2|Osmia bicornis|NOT thiacloprid or imidacloprid|Beadle et al., 2019| ^CYP321A7|Spodoptera frugiperda|λ-cyhalothrin|Li et al.,2024| ^CYP321A8|Spodoptera frugiperda|O:(Fall armyworm) deltamethrin|Chen and Palli 2021| ^CYP321A9|Spodoptera frugiperda|gramin, tricin|He et al., 2023| ^CYP321A16|Spodoptera exigua|chlorpyrifos|Hu et al., 2020| ^CYP321A19|Spodoptera litura|indoxacarb,chlorantraniliprole,λ-cyhalothrin,imidacloprid NOT chlorpyrifos|Li et al., 2023| ^CYP332A1|Spodoptera exigua|chlorpyrifos|Hu et al., 2020| ^CYP332A1|Spodoptera litura|cyantraniliprole (by feeding, not topical)|Li et al., 2023| ^CYP337B3|Helicoverpa armigera |fenvalerate|cited in McLeman et al., 2020| ^CYP402C1|Bemisia tabaci|imidacloprid|Guo et al., 2022| ^[[cyp_clans|CYP4 clan]]|||| ^CYP4D24|Aedes aegypti|permethrin|Reid et al., 2014| ^CYP4G15|Aphis gossypii|cyantraniliprole|Ding et al. 2023| ^CYP4H29|Aedes aegypti|permethrin|Reid et al., 2014| ^CYP4H33|Aedes aegypti|permethrin|Reid et al., 2014| ^CYP4J15v1|Aedes aegypti|permethrin|Reid et al., 2014| ^CYP4S9|Spodoptera litura|abamectin|Liang et al., 2024| ^CYP4S24|Musca domestica|permethrin|Li et al., 2023| ^CYP4CJ1|Aphis gossypii|cyantraniliprole|Zeng et al. 2021| ^CYP4CK1|Aphis gossypii|thiamethoxam|Lv et al. 2022| ^CYP4CK1|Aphis gossypii|cyantraniliprole|Ding et al. 2023| ^CYP4CL2|Panonychus citri| pyridaben| Pan et al., 2023| ^CYP4CS5|Bemisia tabaci|thiamethoxam, clothianidin| Hu et al., 2024| ^CYP4FB1|Laodelphax striatellus|deltamethrin, fenvalerate, etofenprox|Yu et al., 2023| ^CYP340G2|Spodoptera litura|indoxacarb,chlorantraniliprole,λ-cyhalothrin,imidacloprid NOT chlorpyrifos,λ-cyhalothrin|Li et al., 2023| ^CYP380C6|Aphis gossypii|spirotetramat|Pan et al. 2018| ^CYP380C6|Aphis gossypii|cyantraniliprole, a-cypermethrin|Zeng et al. 2021| ^CYP380C40|Myzus persicae|sulfoxaflor|Pym et al., 2022| ^CYP340L25 (called 340L)|Spodoptera litura|no effect on cyantraniliprole tox|Li et al., 2023| ^CYP340AX8 (called 340A)|Spodoptera litura|cyantraniliprole|Li et al., 2023| ^CYP439A1|Laodelphax striatellus|NOT fenvalerate|Yu et al., 2023| ^[[cyp_clans|Mito clan]]|||| ^CYP12A4|Drosophila melanogaster|(OE) lufenuron|Bogwitz et al., 2005| ^CYP12A5|Drosophila melanogaster|(OE) nitenpyram (activation)|Harrop et al. 2018| ^CYP12D1|Drosophila melanogaster|(OE) DDT, dicyclanil|Daborn et al. 2007| ^CYP12D1|Drosophila melanogaster|(OE) malathion|Battlay et al. 2018| ^CYP301B1|Laodelphax striatellus|deltamethrin, fenvalerate, etofenprox|Yu et al., 2023| ^CYP339A1|Spodoptera litura|indoxacarb,chlorantraniliprole,λ-cyhalothrin,imidacloprid NOT chlorpyrifos|Li et al., 2023|