FASTA of the second type of P450 sequences lacking the conserved Cys

Type 2: Mito clan, Hemipteroids (16 sequences) Species / taxonomic position and accession number (from Dermauw et al. 2020, Suppl. File S2)

>Aquarius_paludum-Hemiptera-Gerroidea-GDFO01070937 MESIINTKNSEKLSDKYHLSKLDE AKILSKPFPVDAIDPLSIPGYTPSLSEKPILPKDFIKFTAPATITSYDLVPGPSLLKTVG NIWKYIPLLGTQFVATLIYSMQSLISSYDRRLKYPNVYPYYYLLNKYGPMVRLHGPIGAD ILVMAVNGLDFPLVHIKTRANKRQSLFDSLNTYRRDATPLSYMLNFPKASLRIPDNPTLK IDHHYSSLERITDDFINRRKFVRTYTGAKDDDSHGNDLLKWAMQCTMDVYFKSKRDYMEQ SGSESSKIVDSFIKASKSVRLCETGIQLWRAFTTLTWLDLAEYCKEMDRFIVNEVSQCMT RSSQGKTNGSVVELLLASEELRTTDLLTPLLDLLIINVNMAATTAGFLLYNLSKTPQVQR TLFREVSSVLPKGKGNINQSDLAKLKYLNACITETLRMVPPFPVLSRQIEEDTKIHSFQI PKGTYVQMVNVLPCARGDVCYDDIGRFQAERWTDKTTSLGGDPLLGLPQWQSAPKFNRDL IITQVALLVAKVVREYRIEYPTADVFSDGMVLQGPTTPFNFAFIERVI

>Buenoa_margaritacea-Hemiptera-Nepomorpha-GCXE01028779 DNLLISTSVRRELV YRPLARSPAYSVPFDHLPGPNALKVLGKLFNCVPMATSQLTIASVNQVHHVTHRMGKKME SLSGYSPYSVLFSKFGPLVRLSGLLGGEVVLVKADSHTRNVISTLASESSTYTSLFDSLE AYHRIKNPSHFVSSPCKESDWDILNAKYKDGREFQPEEVFQLQETLTEELIQKTHSMRNS YNEVNDEFRTSIMRWGIECVGRGVSEETGLCSPDVDRLVNPLMAASESLAHCETGLQFWR MMSTPAWNKLVDSCSVLEGLLNWQLKDGLRRLGKKSSGSELVTCPSVEMDLGRSHTSPQQ VLSKVLDTYLVRVNMGVNLSCFTMYNLAKNPRCQSQLFKEIKDKIPDKDIEIEPKVIMDM KYLMGCILETVRLNNPFPVTIKLLDKDIVLQGHKIPRGTHVVMASDVTICDGEKYERPDA FAPERWLEAPTPDQQSQLPLEEGPLALCPFPGHHDRLLTYQQIALLVVKMMQHFVIDYSD TQVSSRNSFLAMPDKSFKFRLTERK

>Chauliops_fallax-Hemiptera-Lygaeoidea-GCXK01007253 MKRQGIILSSRQGLPLSRSVHGPLGSVRAVEMQTAALSVTTNWWRRRRTEAVYVLPL EAVPGPSWKLGSLADLLAQGTTASYLASRYGPLVRLPGPRLIASHPPHIQSLLAASRPDR SPLPTMEEKRNVTLPVRMPEYEHDFSSLTVKYNGQLDFKQNHFNSIIEEASDILIERMHY FKNLQNEVPRFKDELYKWSLQCTFGILFSKDFGFLEDVTVMNEHDIRISSAVQIFSILKE ASVCLVESESGPLGKFFHKRTFENHIDVLHGVLCRHLRVKYLSLVRDPPKKLGLVEKMVL REKMSANDILNRILDIVVLGVNVVVNSVGFIIYHLSKYPGCQGKLLDEVSTYHLSNLQEL PYLNCCLAESMRLRPPFPSLWRETDADVIIHGYGIPRRTPICLLNEIANMREELFPRPSE FSPERWELKSGRPLSYEYNLLPMARVAPLLHAQMAILTAKLTKEFKFEYHCGSIESGGRA LAAPNKQFSFTFI

>Cimex_lectularius-Hemiptera-Cimicoidea-XP_014255591-CYP394A1 MLRIKLIQRLFSLIKRKTTYTATTSPTTSEEQPTSKVLASNVEEEAELDERLGTDDLFFASEHLPFTVMQQHEQIFPKAKPTLLDPLIDETQRVDKSGVCAVPFSQIPAIGGHLWLELCHLFSKCLYAIKGQNDEKLLSWIYPFRIFFDFYGPLVRINTPSKSSVVMLCKPKHILAVQKYDGTHSLRSIIDSMENYRRTRISITMPQYEIDFSQVAEKFKNHLNHRVNDYQYLCNQMAVDFVKRNYLIRDHRCEVPANYNGELCLWSLKCFSAIVFGRDAEYKQDGYTKIVHTLIEVSKALSDCESAPQIWRFLPTTSTSKLAQCFDVLETLLIRNLRMTYLKLGKLSKNVKNETPQPVALLETMILKDKMSTDCIITTLMDLLVVGVNSIANIAGMVLYYLSKSPDVQDRLFWEINLVIPHDLNELFSEDMIHLPLLRACIVETMRLWPPFTHTVRCTSKEIVVNGYTIPKNTNVIMAHQIAFHKNEHFADAKKFEPRRWIGRFSKQLDPLEVMPFCHRQHPIIKELAYRQIAVLIAHMVKNFEIEYNYGEMSYESKILSLPSKPLKFTLKDRH

>Gelastocoris_oculatus-Hemiptera-Nepomorpha-GCXI01030921 MDGLTMMRRWQQLGRMGAIMVRGMADLAKNAENAQLTPKRTDHNRIKGAPLPTTKGP IPEENLQTDSLLLTPAAAPKPKSPHIFRTTSPKASMSSAVGGPMPSGAADGEGVSGGSAK PFMPAVVSQTEESAVTPFKKPQLAMVDKEPRTAVMPFTDIPGPAVFTWINQFWQYLPALD GRFKWVYKVRPYKMLFDEYGPVVRLHGPFGGDIVLLNRPEDIKSLYDQDVRPEGHSILDS LDAYSKFKCQNDINPINAVEFPQLTEKFSDSLEKNLEDFHGAMDQSADELVSMLYVRRNV HEESPTFNQELYKWSLKSMIRTLFDKEASQDTSMCDMTATICVKPLLEASEALGSCECGV QLWRFIPTPSWNQMSNSCDLLMGLLCQNIHAAYMKLEKAKEAARGEMKLSFAESLILKGQ LTPEHMLTKVLDTILVNVNASVNAAGFLMYHLARNPLSQKRVFEEVSSVLPSKDGPLMFD PEFANLKYLNACFTESLRLSPPMPFSTRVLSNDVVIRGYSIPKDTLAILSHESPCQVDDK FYQPDRFSPDRWLEGENGCDAGDLLASVPSHDPLLRQVIHHQAITLVAKVVRNFTLEYNY GPIVRAGNRMFEIPDKLFKLSFVEREQ

>Halyomorpha_halys-Hemiptera-Pentatomoidea-GEDY01046576 MRYRNVFRGIYAKRSIFKGIPRNSYLAHLRSVRKTLLQRIEVDQFARSQ KEEVYVLPFDEIPGPKVPSFIPSKYIVGPIQQAHSTGWFQPYEMLFTRYGPLVRVNGDSL LVSHPRYIEAIMAISLPNRSALSTMERKRRLSLPIRMPEYELDFTELSEKYADLLNFKPN HFNKRIEVASDQLISRMYYTRNLQHEVPNFDEELYQWGLQSMFCCLFSRDCTFLQDPIGN NEFGPKSGIYQTYQTFLNASYCLAEAEAGPLGRLVRQHSVANHIDVMNGILCRNLRTKYL ALWRDTDKELQTDLVEAMILRDKMNSNDILTRLCDIVILGVNIVAHSVGFLIYHLAKSPV YQPMLHEAVMKADSDNLHCIDFMNYCIYESMRLIPPFPSLSRDLDRDIILHGYGIPKGIQ VHMINEVANMRKDMFPQTTVFSPERWPRMGKEPMLPHNYQLLPLAPVAPLLHAHVSVLTA KLVKHFKFEYHYGEIKSGQLLAKPNKPFLFTFIDRDREGIPVTTK

>Largus_californicus-Hemiptera-Pyrrhocoroidea-GCXR01047327 NTSFTLIYFPLINSFFPFLNPMLLIQAKYFLTNNYSIFRNKYYLNHAICRFMPRRILTSTVCSTSEDFLIRTQPEQVFVLPFDKIPGPNLPHWLPSRWVIGPIQQAHTSGKEWIKPFERLFARFGPLVKLDGDTLLASLPRHIEKILTASRPNRSSLSVMESKRKQTLPVRMPEYDTDFSYLSTKYSSHLDFKPDHFHSIIDGSSDKLIARMVYFRNLQxEVPHFNDELYKWGLQCMLGCLFSKDFCFLEDVSKQIDCDSLNSGAAQILGTFKGAAQCLAEAEAGPIGKFLKQHIFEDHIDVLHGILCRQVRIKYLSLAREPPSKLGLVEEMILKKKMSANDILTKLLDTIILGVSIVAHSVGFMIYQLTKYPGCQGKLFDELSTYHLSNVQDLPYLKCCVAESMRLRPPFPYISRELDDDVIIHGYGIPRGTHVYLINEVAYMRKELFPRPKEFSPERWELKSGRPLSYEYHLLPMTSIAPLLRVQIDILIAKLAKKFKFEYHYGKISSYGRVLATPSAPFRFTFIDRKP

>Murgantia_histrionica-Hemiptera-Pentatomoidea-GECQ01183933-CYP3221A1 MRYRNVFQEVNAKRSIFKGMPWSSYLGQLRPLQKSLLQAIEVDQFARSQKEEVYVLPFDEIPGPKVPSFVPSKYIVGPIQQAHSTGWFQPYEMLFTMYGPLVRVNGDSLLVSHPRYIEAIMAISRPNRSALSTMERKRRLSLPIRMPEYELDFTYLSKKYADILNFKPNHFNKRIEVASDQLISRMYYTRNLQHEVPNFDEELYLWGLQSMFSCLFSRESSFLQDPTGHHKFGPKSGVYQTYQSFLNASYCLAEAEAGPLGRLVRQRSVANHIDVMNGILCRNLRTKYLALWRDSEKLQADLVEAMILRDKMNSDDILTRLCDVVILGVNIVAHSVGFLIYHLAKSPVYQPTLHESVTKADSDNLHNIDFMNYCIYESMRLIPPFPSLSRDLDRDIILHGYGIPKGIQVHMINEVANMRKDMFPQTRLFTPERWPRMGKEPMLPHNYQLLPLAPVAPLLHAHVSVLTAKLVQHFKFEYHYGDINSGQLLAKPNKPFLFTFIDRSK

>Oncopeltus_faciatus-Hemiptera-Lygaeoidea-GCXY01042292 MNISPRNHKVLSCLKANNFDLFLKNVESTSR MQSFVLSNMAVSPGVDDSRVFRRRVEAVYVLPLEAVPGPGWPGRLLFGPISLQLHLAAPG SLAARYGPLVRLPGPTLLASHPRHIQRLLAASRPDKSALPTMEAKRKDTLPVRMPEYETD FSHLATQYNGQLDFKPDHFNSIIEEASNNLIERMNYLINLQNEVPCFKDELYKWSLQCTF GCLFSKDFGFLEDTSLMNEHDIRISGAVQIFSTFKEASRCLVEAEAGPLGKIFKKRTFED DIDVLHGVLCRHLRVKYLSLSRDPPSKLGLVEKMVLKEKMSANDILNMILETVVLGVNIV AHSVGFIIYHLSKYPGCQGKLFDEVSTFHLSNLQELPYLNCSIAESMRLRPPFSYLSRDL DDDVIIHGYGIPRGTQVYLANEIANMREELFPRPNEYSPERWELKSGRPLSYEYHLLPMK RIAPLLQSQIAILTAKLTQKFKFEYHYGTIGSGGRALATPNKPFSFT

>Pagasa_sp-Hemiptera-Nabidae-GCXU01023568 MLRIILQLRRSLVLKGRAQLISTNSIPSENDDEQERNEIPGPDDLFFSSEHLPCSVSQPD EQIFPKAKPTLLDPPVDGAKHVNKSGLCAVSFQEIPSVGGSLWIKFCNATSRYFAGAKVE PESSLVSWIYPFKKLFDKYGPLIRVITPTRNDVVLLCKPQHILMIKKHDEPHAVRSVIDS MEHYRRSRLSIKMPQYELDFSKVAEKFKNQLNHRVNDYQLLCNQMALDFVKRIYAIRDHR FQVSDSYNEELCLWSLKCFSGVVFGRDAESKPDGYTKVVKTLLELCKILGDCESTPQLWR FVSTPSTSKLSECFDILEALVLRNLRMTYLKLGQMTENDKESSSQPLALLDSMILKDKMS TDNIITILMDLLVLGVNSTANIAGMVLYYLSKYPEIQDRLFWEINLVIPHDLSELFSEDM VHLPLLRACIIETIRLWPPFNHTVHCTSKEIIVSGYKIPKYTQVIMAHDIAFHKEDHFAD AKKFEPRRWVGRFSKQLDPLEVMPFCYRQHPVIKELAYRQIAVLIAHMVKNFEIEYNYGD IEYDGGRLLLSAASKPLKFTFRDR

>Panstrongylus_lignarius-Hemiptera-Reduvioidea-GFTR01007413 MSSVFPKAVSTTLERFKTNSKDMVYAVPFDEMPGPSSLRSIANF YRHIPIISSQLTTLFLNRAQQVGKLPTATGINQEGSWIQSVMSSIRPYDLLFERYGPVLR LHGPFGGDIVMLSLPEHIETVYNVDSQYPVRALLDSMEVYRKSKVIPNMPSYEGDYELLR EALKYSLDLKLEDFDTMLEQIADDLIHRISCIRNMQDEVPDNFHKELHKWGLECWSQIIF NNKVGFLQKNNLSDLSEAGRMLNLLIEASQALRNCESGLQFWRIWPTFSWTKLTSAIDML EGLLCRNLRVNYIKLSKMNKNAKDVQRLCLMDAMIIKEKLTSDEIITTVLDLLIIGVTSV SNSAGFAIYHLAKTPRAQTRLLQEIVQFLPSKDSKLFSHNLSNMNYLKSCVLESLRLRPP FPYTTRCLSKDLVIHGYTVPRGTLLVMANEVAYHKDENFECALRYEPERWMDAFSNPFDP LAAMPFCHGQTELIKQIAYRQLAILIAKLLRNFKFEYHYGRINQDGKVLAIPKKPFRFRF VERAE

>Phymata_pennsylvanica-Hemiptera-Cimicomorpha-GCYI01036023 MSSITPANILFKHFKIKIMINRSFCEKLLELNVNNLKLDEENVMKGAVTNMDIS AQQLDDLRANNEICEERLNSDDLLITLSRSKGLSSVFPRAPTSLSDFKTDHKDAVYAAPF DEIPGPSLLKALANVFHYIPMLSTNFTAVFLNKAHQVTKCSVISSGTQLEKAWLPRAIST LSPYNLLLEHYGPIIRLSNPLGGEVVVLTLPEHISAVYRADGQHPVRAIFDSMETYRKIR TPSNMPNFDGDYDLMSKKLRINYTEEDFDLLLESVSEELIKRIGSVRNMQDEVPDSFSEE LHKWGLECWSQYMLNRRIGFLTDSNTSIYSESGRMLKLLIEAGHYLRNCESGLQLWRLFS TYSWTKLTSAIDILEGLLCRSLRLNYLKLNDISEASNNEEVYNRTCLLDAMIVKDKLTSD EILTAMIDSLIIGVPSVCNSAGFLMYHLAKNPKVQNRLFNELMEALPTKTSQFQPNQISN MPYLKACVVESLRLIHPFPYTVRFLSKDMVIYGYSVPRGTLLVMANEIAYHKEEYYENAL RFEPERWIDADTKINFDPLAAMPFCHSQTEVIKNLAYRQLAVLVAKILRNYKLEYHYGQI RHDGKVLAIPKRPFRFRFVQREV

>Plea_minutissima-Hemiptera-Nepomorpha-GDES01037678 MKKTMKNIHCILVIESGLCLAVQRRGISVLPWRQREKEVLTNIA DSKVIPSLDPPPPHESPGFISEPPTIKEEPPLNTDNLFMAANQHPPPKKILADSKAKACA SMNLVQSDVKCFASFGELPGPSALKVINKGWSYIPLFGAQSSISVLSHAQGFFNRLGKRF KWMLRMRPFNYLFEEYGPVVRVGTILGGDVVLIKRSEEVRSLIQSLDTPTGSSSLVDSLE NYRKWKLPAPLPLSFTDGQGDKSWLKLEETLQEKLQFKAEDFMSVQEQISDEFIAKIFSE RTAQEEFTDEFRMNMFKWGLECMSATLFNERQGFMEVGHRGTSVTEASRMLPAFLTASEG LSACETGLQMWRLLPTKGWNMLTKSCDILEGFLCRNMRASHIKLEKMASGIQDIKNPSLV QALILNEHLTPEQTLTKLLDIFLIGVNTAVNSASFLLYFLAKYSRVQNKLFKELIESLLN QGSKFTPEEFKKQKYLMACVIETLRMKTPFPFMIRKLEKDVVLHGYIVPKGTHLLMANIM ELMSEEKFEEPERFLPERWHLEAPLSVEDDPLAAAPFSNDLTRQIIYQQVAILIAKVVRN FSLEYHYGPIHCNDHFLCPPNRPFKLRAADRAQ

>Rhodnius_prolixus-Hemiptera-Reduvioidea-GAHY01000067-CYP394B1 MFKVGTIFSTLFASCFRWFKKLLSGILLFRRSSKDFLRNAVVDNIYVKTQPTSEIRQGTQIPKTCTEANNANIDTAEERLGTDDLLLTISKSKMSSVFPKAVTATLERFKTNSKDVVYAVPFDEMPGPSSLRSIANVYRHIPVISTQLTTLFLSKAQQVGKLSPSTGINQEGSWIQSVMSSFRPYDLLFERYGPVLRLHGPFGGDIVMLSLPEHIETVYNVDSQYPVRALLDSMEVYRKSKVTPNMPSYEGDYELLREALKYSLDLKLVDFDSMLEQIADDLIHRISSNRNMQDEVSDNFHKELHKWGLECWSQLIFNNKVGFLQKNNLSDLSEAGRMLNSLIEASQALRNCESGLQFWRILPTYSWTKLTSAIDMLEGLLCRNLRLNYIKLSKMNRNAKDAQRLCLLDAMIIKEKLTSDEIITTVLDLLIIGVTSVSNSAGFVIYHLAKTPRAQTRLLQEILHYLPTKDSKLLSYDLSNMNYLKSCVLESLRLRPPFPYTTRCLSKDLVIHGYTVPRGTLLVMANEVAYHKDENFECALRYEPERWMDEFSNPFDPLAAMPFCHGQTELIKQIAYRQLAILIAKLLRNFKFEYHYGRIHQDGKVLAIPKKPFRFRFVERAE

>Sehirus_cinctus-Hemiptera-Pentatomoidea-GCZB01036540 KQLKVFFLVVYLYKNLCVFSFCEILMRFRHDLQGIYTKRNLFRGSPKSSYLAIQRSLQKS LLPNIEVDFYARWQKEEVYVLPFDKIPGPKVPSFIPSKYIIGPIQQAHSSGFHPYERLFA TYGPLVRVNGDSLLVSHPRYIATILASSRTNRSALSTMERKRRLSLPIRMPEYEMDFTQL SEKYGEQLNFKHNHFNKYIEVASDQLISRIYYCRNLQHEVPHFSDELYKWGLQSMFSCLF SRDCGFLQDPTGGKSCKPNSGVTQTYQSFLHASICLAEAEAGPLGRLVCQRSIANHIDVM NGILCRNLRAKYIELSRNIGNPDKRPDLVEAMILREKMNSNDILTRLCDIVILGVNIVAH SVGFIVYHLAKNPIYQGTLYNDIARADQSNLNNIDFLNYCIYESMRLRPPFPYLSRDLDC DIVLHGYGIPRGIQVHMINEVANMHTFPQPKMFMPERWVQMGNDPLLPFNYQLLPLAPVA HLLHAHISVLTAKLVRHFKFEYHYGKIKSGGQLLATPNRPFIFTFIERNK

>Velia_caprai-Hemiptera-Gerroidea-GAUO02024238 MEIQRVIDPAKRP VISDYKPIPLEKPVSPVLPKEFKKFPEEATASAFEAIPGPTVLRSVGNIWKYVPILGTQI VSTLMYTMQSLATSYDRGMKYPSLNPYHYLLNRYGPVVRLHGPLGADIVLLAVNGQDFPL VHTKLKGNNYQSLFDSLNVYRRETPPLTTTLLTMNPKTSKMPDNTTLSVDQYYSTIENIT DDFIKRKKFIKSYSSGEHHTEGQENDLFKWALQCTTEVYLKTGRNYLDDAASNNESNKMS EYLVRVSKSVKLCETGIQLWRAFTTFTWMDLTEYCKHLDRHIVDEVNRTLQDIKQGKSSG SVLESLIYTDELRSTDTLTPLLDVLLINVNVAASTAGLVLYNLGRTPQVQRNLLREIGSV LPKGGKSITRSDLTKLKYLNACITETLRMAPPFPMLSRQLEEDTNINGFDIPKGTYIQMV NVVACSRGDYAYEDMGRFQADRWTEKEHSKGQVTTPPHTLGGDPLTGLPQWNTCPDFNRD LVLTQISLLVAKIVRDYRIEYPNYSLHSDGMVLAGSTTPIDLAFTDR