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--- cnglc [2026/02/18 15:49] – renefeyereisen
+++ cnglc [2026/02/18 15:49] (current) – renefeyereisen
@@ Line 9: / Line 9: @@
 {{ :cnglcs.jpg?400 |}}
-//Heliconius// butterflies also produce linamarin and lotaustralin and have close homologs to CYP405A2 and CYP332A3.
+//Heliconius// butterflies also produce linamarin and lotaustralin and have close homologs to CYP405A2 and CYP332A3. The analysis of CYP405 and CYP332 genes in Lepidoptera (Zagrobelny et al., 2018) shows that they are members of relatively small subfamilies present in both cyanogenic and noncyanogenic species. In //[[sexigua|Spodoptera exigua]]//, CYP332A1 metabolizes chlorpyrifos (Bo et al., 2020). The ability to make cyanogenic glucosides may have been derived from an ancestral ability to detoxify aldoximes (Zagrobelny et al., 2018). Later the CYP405s evolved to generate aldoximes, and a UGT was recruited into the pathway to establish de novo biosynthesis of CNglcs.
-The analysis of CYP405 and CYP332 genes in Lepidoptera (Zagrobelny et al., 2018) shows that they are members of relatively small subfamilies present in both cyanogenic and noncyanogenic species. In //[[sexigua|Spodoptera exigua]]//, CYP332A1 metabolizes chlorpyrifos (Bo et al., 2020). The ability to make cyanogenic glucosides may have been derived from an ancestral ability to detoxify aldoximes (Zagrobelny et al., 2018). Later the CYP405s evolved to generate aldoximes, and a UGT was recruited into the pathway to establish de novo biosynthesis of CNglcs.