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--- cyp307page [2025/07/25 06:10] – external edit 127.0.0.1
+++ cyp307page [2025/12/17 09:40] (current) – renefeyereisen
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 Rewitz and Gilbert (2008) noticed the tail to tail location of CYP307A2 and the neverland (nvd) gene in //Daphnia pulex//, //Anopheles gambiae// and //Drosophila willistoni//. Dermauw et al.(2020) reported that in //Drosophila melanogaster// the two genes are only 0.1cM apart. The synteny is also maintained in //Aedes aegypti//, at least four lepidopteran species, as well as //Nasonia vitripennis//, //Cephus cinctus//, //Neodiprion lecontei//, //Athalia rosae// (tail to tail), //Myzus persicae//, //Frankliniella occidentalis//, //Pediculus humanus// and //Zootermopsis nevadensis//. In //Aphis gossypii// there are four genes, one CYP307A (XP_027846257) located tail to tail with an nvd pseudogene (XP_027846250) and nvd (XP_027846249) and two more in tandem array (XP_027848023 and XP_027848010), as well as one CYP307B gene (XP_027854219). CYP307A2 and neverland therefore form a functional cluster.
-More distant from the CYP307A and 307B sequences are clades of CYP307 in Malacostraca, Cirripedia as well as Diplura, whose relationships to the CYP307A/B clades are still unclear. There are two more clades, one includes //Strigamia// CYP307 and most Chelicerata, and another is specific for Acariformes. In none of these genomes can synteny of CYP307 with nvd be detected. While the TSA of the millipede //Chamberlinius hualienensis// revealed no CYP307, its presence in millipedes can be shown in the genomes of //H. holstii// and //Trigoniulus corallinus//. In the bark scorpion, CYP307M was recently duplicated, with the two genes differing by just four nucleotides, but with different neighboring genes, while the horseshoe crab has three CYP307 genes.
+More distant from the CYP307A and 307B sequences are clades of CYP307 in Malacostraca, Cirripedia as well as Diplura, whose relationships to the CYP307A/B clades are still unclear. There are two more clades, one includes //Strigamia// CYP307 and most Chelicerata, and another is specific for Acariformes. In none of these genomes can synteny of CYP307 with nvd be detected. In the bark scorpion, CYP307M was recently duplicated, with the two genes differing by just four nucleotides, but with different neighboring genes, while the horseshoe crab has three CYP307 genes.
 ====CYP307 structure and function====