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--- mito_clan [2025/07/25 06:10] – external edit 127.0.0.1
+++ mito_clan [2025/09/11 09:41] (current) – renefeyereisen
@@ Line 1: / Line 1: @@
-====== The mitochondrial P450 clan (Mito clan) ======
+====== The mitochondrial P450 clan (Mito clan) (= CYP11 clan) ======
-Sequences belonging to this clan are considered to be located on the inner membrane of mitochondria, as are the vertebrate members of this clan (CYP11, CYP24, CYP27). This clan has therefore the "mitochondrial" designation. This may be unfortunate and potentially confusing, because clan names refer to similarities in sequence, not subcellular localization, and because it is far from certain that each and all Mito clan P450s are actually mitochondrial.//This clan probably should have been called// the **CYP11 clan** (as the other clans are named after the first family of the clan).
+Sequences belonging to this clan are considered to be located on the inner membrane of mitochondria, as are the vertebrate members of this clan (CYP11, CYP24, CYP27). This clan has therefore the "mitochondrial" designation. This may be unfortunate and potentially confusing, because clan names refer to similarities in sequence, not subcellular localization, and because it is far from certain that each and all Mito clan P450s are actually mitochondrial.
+//This clan probably should have been called// the **CYP11 clan** (as the other clans are named after the first family of the clan).
 The Mito clan is generally small, down to 4 sequences in the collembolan //[[Sinella|Sinella curviseta]]//, but can be larger than the CYP2 or CYP4 clan as in the cat flea //[[catflea|Ctenocephalides felis]]// where Mito clan P450s comprise 30% of the CYPome (Feyereisen, 2022).