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--- strangeseqs [2025/07/25 06:10] – external edit 127.0.0.1
+++ strangeseqs [2026/01/16 10:37] (current) – renefeyereisen
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 **3-CLT1 - Cys-less type 1** evolved about 400 MYA and can be found as a full-length single sequence in 106 surveyed species of Polyneoptera and Condylognatha.
- The figure below (Fig.13 from Dermauw et al., 2020) shows its distribution. It includes the CYP408 sequences described previously [[https://doi.org/10.1098/rstb.2012.0428|Sezutsu et al., 2013]]. This first type is from the [[cyp3 clan|CYP3 clan]]. It is most noticeable by the lack of recognizable Cys pocket motif with in some cases Ser at that position (see WebLogo) and is closely related to CYP360 sequences (consensus sequence below the WebLogo showing the difference in the P450 signature).  {{ :cyslesstype1.jpg |WebLogo of the first type, compared to consensus CYP360}}
+ The figure below (Fig.13 from Dermauw et al., 2020) shows its distribution. It includes the CYP408 sequences described previously [[https://doi.org/10.1098/rstb.2012.0428|Sezutsu et al., 2013]]. This first type is from the [[cyp3 clan|CYP3 clan]]. It is most noticeable by the lack of recognizable Cys pocket motif with in some cases Ser at that position (see WebLogo) and is closely related to CYP360 sequences (consensus sequence below the WebLogo showing the difference in the P450 signature).Interestingly, [[functions|RNAi]] of CYP408 in three species increases toxicity of several insecticides.  {{ :cyslesstype1.jpg |WebLogo of the first type, compared to consensus CYP360}}
 **M-CLT2 - Cys-less type 2** evolved about 360 MYA in Heteroptera (“true bugs”), forming a monophyletic group of 17 sequences including CYP394A1 of //[[cimex_lectularius|Cimex lectularius]]//, CYP394B1 of //[[rhodnius_prolixus|Rhodnius prolixus]]// and CYP3221A1 of //Murgantia histrionica// belonging to the [[mito_clan|mito clan]] and closely related to CYP334 enzymes . These sequences lack the WxxxR motif but have ExxR and PERW motifs, yet lack a Cys pocket recognizable motif.