Arthropod P450 Dokuwiki

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====== Drosophila melanogaster P450 pseudogenes ======





**CYP6A16P** on chr. 2L has a frameshift mutation in the genome. NCBI proteins for CYP6A16 override this frameshift and claim :  exception="annotated by transcript or proteomic data" and "complex mutation, may be evolving pseudogene". 

The two versions are below:

Drosophila_melanogaster-CYP6A16P-genome
MDFTLLLLTSLLSFLLGYLRYRFTYWELRGIPQLRPHFLFGHFFRLQSVHYSELLQETYDAFRGSAKVAGTYVFLRPMAVVLDLDLVKAVLIRDFNNFVDRRSFHGDPLTANLFNLQGEEWRNLRTKLSPTFTSGKMKYMFGTVSTVAQQLGGTFDELVGSQGAVLELHDLMARYTTDVIGSCAFGTECSSLREPQAEFRQVGRRIFRNSNRSIRWRIFKMTYLSSLAKLGLPVRILHPDITKFFNRIVRETVELRERENIRRNDFMDLLLDLRR**X**KGLTMEQMAAQAFVFFVAGFETSSSNMSYALFELAKNQDVQQKLRMEINDSIGKHGKLTYEAMMEMPYLDQTITETLRKYPALSSLTRLASEDYEIPSPDGGDPVVLEKGTSVHIPVLAIHYDPEVYPEPHEFRPERFAPDACRERHPTAFLGFGDGPRNCIGLRFGRMQVKVGLITLLRRFRFSLPPGSPTQLKVTKRNLILLPSDGVRLQVDPVESRLM

Drosophila_melanogaster-CYP6A16-NCBI-protein
MDFTLLLLTSLLSFLLGYLRYRFTYWELRGIPQLRPHFLFGHFFRLQSVHYSELLQETYDAFRGSAKVAGTYVFLRPMAVVLDLDLVKAVLIRDFNNFVDRRSFHGDPLTANLFNLQGEEWRNLRTKLSPTFTSGKMKYMFGTVSTVAQQLGGTFDELVGSQGAVLELHDLMARYTTDVIGSCAFGTECSSLREPQAEFRQVGRRIFRNSNRSIRWRIFKMTYLSSLAKLGLPVRILHPDITKFFNRIVRETVELRERENIRRNDFMDLLLDLRR**QENG**KGLTMEQMAAQAFVFFVAGFETSSSNMSYALFELAKNQDVQQKLRMEINDSIGKHGKLTYEAMMEMPYLDQTITETLRKYPALSSLTRLASEDYEIPSPDGGDPVVLEKGTSVHIPVLAIHYDPEVYPEPHEFRPERFAPDACRERHPTAFLGFGDGPRNCIGLRFGRMQVKVGLITLLRRFRFSLPPGSPTQLKVTKRNLILLPSDGVRLQVDPVESRLM

**CYP6A15P** is a C-terminal gene fragment just upstream of CYP6A13 on chr. 2R 

Drosophila_melanogaster-CYP6A15P
AFTVTNSKLAKKLKMKILRDDLTDFFLSVVKPALSGMTLWTSPPSGGRSSRQGGSKFDLSHNWTLEQMAAQAIVFFLAGFETSSSTMSSCKYELALQPEI*NQIRDEIERVLEGNAITYDALAKINYPEQVLSETLRKHXXXQLIKFLLETQESFRVRNTELIVEKGTSLLIPVHSVHYDPHLYPHPKLFDSSRLKAYKSNSRHPFAYLPFGTFGPRSCIGLRFGKMQAKIGIVSALQXXXSDLTDIPLASDTRSAIVERI

**CYP6T2P** is very degraded pseudogene on chr. 2L with several frameshifts and gaps.

Drosophila_melanogaster-CYP6T2P 
MVIAFFIFLXCAALAVGSVVLLPLIALLAVWLWQRRHFRIWRRLGVPYLPAAPVLGNVLNVXCCFGDQFRELYERKEAAGRAIVGINVLHSHALLLRDPALIRRILVEDFPEFSSSFKSTDAIRDTMGSGNLLFTKYKTWWETHKIFAXLYGLLERI*QNLEAHMKKKXLNGAESVELEVKQLCALFTTDILQXXXSLQNPEAEFRPMCIEVNDPKPKRLSHHLFTXRVRTHLYSEEYERFMRKSMNYVLAQRAEN*EKRYDLIDMFLQMHRTETAEGIIHRPDFYVAQAAFXLLAGFDTSSSFALYELAKNPTIEHRLQAELRVDLQSSHNHQLSYDTLTGLVYLRQVLEDXXXLPFGAGPRGCIGTLLGQLGIKVGLLHTLKHFRVELCERTLPEMRFDP*ASVLTAHNGTFLRFVRNSL

**CYP9F3P** located just downstream of CYP9F2, this sequence has a deletion of part of exon 2 and 3, as well as intron 3. It lacks the heme-liganding Cys region, and with just 433 aa, it is a pseudogene.

Drosophila_melanogaster-CYP9F3P
MLWEFLALFAIATALFYRWASANNDFFKDRGIAYEKPVLYLGNMAGMFLRKRAMLDIVCDLYTKGGSGKFFGIFAQRQPLLMVRDPDLIKQITIKDFDHFINHRNEFDTSSDDDPHDMSNLFSSSLFSMRDARWKDMRSTLSPAFTGSKMRQMFQLMNQVAKEAVDCLKQDDSRVQENELDMKDYCTRFTNDVIASTAFGLQVNSFKDRENTFYQMGKKLTTFTFLQNMKFILLFALKSLNKILKVEIFDRKSTQYFVRLVLDAMKYRQEHNIVRPDMINMLMEARGIIQTEKTKASAVREWSDRDIVAQCFVFFFAGFETSAVLMCFTAHELMENQDVQQRLYEEVQQVDQDLEGKELKYLDQVVSEVLRKWPPAIAFDRECNKXXXEAKAVIYYLLKDYRFAPAKKSCIPLELISSGFQLSPKGGFWIKLVQRN