Arthropod P450 Dokuwiki

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====== Transgenic expression ======

in Drosophila unless indicated otherwise O: (other). Transgenic overexpression in the same organism is indicated as (OE). Result is lower toxicity or metabolism of the listed chemical(s) unless indicated otherwise (i.e. bioactivation leading to higher toxicity).


|^CYP^species^transgenic expression^reference^
^[[cyp_clans|CYP2 clan]]||||  
^CYP15C1|Bombyx mori|O:(Bombyx) rescues mod mutation  |Daimon et al., 2012| 
^CYP303A1|Drosophila melanogaster|rescues null mutations  |Wu et al., 2019|  
^CYP304A1|Aedes albopictus|haedoxan A|Pei et al., 2022| 
^CYP392A11|Tetranychus urticae|fenproximate|Riga et al., 2015| 
^CYP392A16|Tetranychus urticae|abamectin|Riga et al., 2014; 2020|
^CYP392D8|Tetranychus urticae|no effect on abamectin toxicity|Xu et al., 2023|
^[[cyp_clans|CYP3 clan]]|||| 
^CYP6A36|Musca domestica|permethrin|Li et al. 2023|
^CYP6A51|Ceratitis capitata|λ-cyhalothrin, deltamethrin|Tsakireli et al. 2019|
^CYP6D1|Musca domestica|benzo[a]pyrene|Korytko et al., 2000|  
^CYP6D10|Musca domestica|permethrin|Li et al., 2023| 
^CYP6G1|Drosophila melanogaster|(OE)DDT|Daborn et al. 2002, Daborn et al., 2007|
^CYP6G1|Drosophila melanogaster|(OE)DDT, dicyclanil, nitenpyram|Daborn et al., 2007, Chung et al. 2007|
^CYP6G1|Drosophila melanogaster|(OE)azinphos-methyl|Battlay et al. 2016|
^CYP6G1|Drosophila melanogaster|(OE)imidacloprid|Denecke et al. 2017|
^CYP6G1|Drosophila melanogaster|(OE)bendiocarb, imidacloprid, malathion|Luong et al., 2022|
^CYP6G2|Drosophila melanogaster|(OE)nitenpyram, diazinon|Daborn et al. 2007|
^CYP6G2|Drosophila melanogaster|(OE)imidacloprid|Denecke et al. 2017|
^CYP6G4|Musca domestica |propoxur|Zhu et al., 2022|
^CYP6G4 wt & mut|Musca domestica |propoxur|You et al., 2023|
^CYP6G4|Musca domestica |chlorpyrifos, tetramethrin, methomyl, acetamiprid, imidacloprid, NOT permethrin |Zhu et al., 2023| 
^CYP6M2|Anopheles gambiae|pyrethroids, DDT, bendiocarb|Stevenson et al., 2011 Mitchell et al., 2012 Edi et al., 2014| 
^CYP6M2|Anopheles gambiae|O:(A.gambiae) pyrethroids, malathion(activation)|Adolfi et al. 2019| 
^CYP6M7|Anopheles funestus|pyrethroids|Riveron et al.,2014|  
^CYP6P3|Anopheles gambiae|pyrethroids, bendiocarb |Muller et al., 2008 Edi et al., 2014|
^CYP6P3|Anopheles gambiae|O:(A.gambiae) pyrethroids|Adolfi et al. 2019| 
^CYP6P3 (E205D allele)|Anopheles gambiae|pyrethroids, propoxur,bendiocarb, NOT DDT |Kengne-Ouafo et al., 2024|
^CYP6P4a Mwi|Anopheles funestus|permethrin, deltamethrin|Tatchou-Nebangwa et al., 2024|
^CYP6P4a Ghana|Anopheles funestus|permethrin, deltamethrin, a-cypermethrin|Tatchou-Nebangwa et al., 2024|
^CYP6P4b Ghana|Anopheles funestus|permethrin,deltamethrin,a-cypermethrin |Tatchou-Nebangwa et al., 2024|
^CYP6P4b Moz|Anopheles funestus|permethrin,deltamethrin, a-cypermethrin|Tatchou-Nebangwa et al., 2024|
^CYP6P5|Anopheles albimanus|pyrethroids|Kusimo et al. 2022|
^CYP6P9a|Anopheles funestus|pyrethroids|Riveron et al., 2013 Ibrahim et al., 2015| 
^CYP6P9a|Anopheles funestus|clothianidin, chlorfenapyr (activation)|Tchouakui et al., 2024| 
^CYP6P9b|Anopheles funestus|pyrethroids|Riveron et al., 2013 Ibrahim et al., 2015| 
^CYP6P9b|Anopheles funestus|clothianidin, chlorfenapyr (activation)|Tchouakui et al., 2024| 
^CYP6P12|Aedes albopictus|permethrin|Ishak et al. 2016| 
^CYP6W1|Drosophila melanogaster|(OE) DDT|Schmidt et al. 2017|
^CYP6Z2|Anopheles coluzzi|a-cypermethrin, deltamethrin, clothianidin(higher toxicity)|Ibrahim et al., 2023| 
^CYP6AA1|Anopheles funestus|pyrethroids|Ibrahim et al., 2018|
^CYP6AB12|Spodoptera litura|cyantraniliprole|Li et al., 2023|
^CYP6AB45|Chilo suppressalis|no effect on chlorantraniliprole, abamectin, triazophos, sinetoram tox.|Wang et al., 2024|
^CYP6AB58|Spodoptera litura|no effect on cyantraniliprole tox.|Li et al., 2023|
^CYP6AB59|Spodoptera litura|cyantraniliprole|Li et al., 2023|
^CYP6AE44|Spodoptera litura|abamectin|Liang et al., 2024|
^CYP6AE70|Spodoptera exigua|chlorpyrifos, cypermethrin, deltamethrin|Hu et al., 2024|
^CYP6AE178|Hyphantria cunea|cytisine, coumarin| Li et al., 2024|
^CYP6AN4|Spodoptera litura|cyantraniliprole, by feeding, not topical|Li et al., 2023|
^CYP6AQ83|Solenopsis invicta|flonicamid| Zhang et al., 2024|
^CYP6AS161(called 6A14)|Solenopsis invicta|flonicamid|Zhang et al., 2023| 
^CYP6AY1|Nilaparvata lugens|imidacloprid|cited in McLeman et al., 2020| 
^CYP6AY3v2|Laodelphax striatellus|imidacloprid|Wang et al. 2017| 
^CYP6BG1|Plutella xylostella|chlorantraniliprole, cypermethrin, NOT abamectin|Li et al., 2017|
^CYP6BG1|Plutella xylostella|chlorantraniliprole|Mallott et al., 2019| 
^CYP6BQ9|Tribolium castaneum|deltamethrin|Zhu et al., 2010|  
^CYP6BQ9|Tribolium castaneum|O:(Fall armyworm) deltamethrin|Chen and Palli 2021|
^CYP6BQ23|Meligethes (Brassicogethes) aeneus|deltamethrin|Samantsidis et al., 2020| 
^CYP6CM1vQ|Bemisia tabaci|imidacloprid, nitenpyram|Daborn et al., 2012|
^CYP6CM1(A387G)|Bemisia tabaci| imidacloprid, clothianidin|Pym et al., 2023a|
^CYP6CS1|Nilaparvata lugens|pymetrozine|Wang et al., 2021| 
^CYP6CS1|Nilaparvata lugens|pymetrozine, flonicamid, imidacloprid,afidopyropen, nitenpyram|Lin et al., 2025|
^CYP6CX3|Bemisia tabaci| cyantraniliprole|Zhang et al., 2022|
^CYP6CX4|Bemisia tabaci| flupyradifurone|Zhang et al., 2024|
^CYP6CY3|Myzus persicae nicotianae|nicotine, clothianidin|Bass et al., 2013| 
^CYP6CY3|Myzus persicae nicotianae|nicotine|McLeman et al., 2020| 
^CYP6CY4|Myzus persicae nicotianae|nicotine|McLeman et al., 2020| 
^CYP6CY5|Aphis gossypii|cyantraniliprole|Ding et al. 2023| 
^CYP6CY7|Aphis gossypii|cyantraniliprole, a-cypermethrin|Zeng et al. 2021|
^CYP6CY9|Aphis gossypii|thiamethoxam, imidacloprid|Lv et al. 2022|
^CYP6CY9|Aphis gossypii|cyantraniliprole|Ding et al. 2023|
^CYP6CY18|Aphis gossypii|imidacloprid|Lv et al. 2022|
^CYP6CY19|Aphis gossypii|cyantraniliprole|Ding et al. 2023|
^CYP6CY21|Aphis gossypii|cyantraniliprole, a-cypermethrin|Zeng et al. 2021|
^CYP6CY22|Aphis gossypii|imidacloprid|Lv et al. 2022|
^CYP6CY22|Aphis gossypii|cyantraniliprole, xanthotoxin, quercetin, 2-tridecanone,tannic acid, nicotine|Ding et al. 2024|
^CYP6CZ1|Aphis gossypii|thiamethoxam|Lv et al. 2022|
^CYP6CZ1|Aphis gossypii|cyantraniliprole|Ding et al. 2023|
^CYP6DA1|Aphis gossypii|cyantraniliprole|Ding et al. 2023|
^CYP6DB1|Aphis gossypii|thiamethoxam|Lv et al. 2022|
^CYP6DB1|Aphis gossypii|cyantraniliprole|Ding et al. 2023|
^CYP6DB3|Bemisia tabaci|imidacloprid, thiamethoxam|Wei et al., 2023|
^CYP6DD1|Aphis gossypii|cyantraniliprole|Ding et al. 2023|
^CYP6DP1|Trialeurodes vaporarium|imidacloprid,nicotine|Pym et al., 2023b|
^CYP6DP2|Trialeurodes vaporarium|imidacloprid,nicotine|Pym et al., 2023b|
^CYP6DP3|Bemisia tabaci|imidacloprid,nicotine|Pym et al., 2023b|
^CYP6DP5|Bemisia tabaci|imidacloprid,NOT nicotine|Pym et al., 2023b|
^CYP6EM1|Bemisia tabaci|dinotefuran|Huang et al., 2024|
^CYP6EM1|Bemisia tabaci|thiamethoxam|Huang et al., 2025|
^CYP6ER1|Nilaparvata lugens|imidacloprid|Pang et al., 2016|
^CYP6ER1|Nilaparvata lugens|imidacloprid|Zimmer et al., 2018|
^CYP6ER1vA|Nilaparvata lugens|imidacloprid,nitenpyram,cycloxaprid; NOT sulfoxaflor,triflumezopyrim,pymetrozine|Gong et al., 2023|
^CYP6FJ3|Sogatella furcifera |pymetrozine|Gong et al., 2023|
^CYP6FU1|Laodelphax striatellus|NOT fenvalerate|Yu et al., 2023|
^CYP6FV21|Bradysia odoriphaga|imidacloprid, λ-cyhalothrin |Zhang et al., 2024 |
^CYP6QE1|Bradysia odoriphaga|imidacloprid, λ-cyhalothrin|Zhang et al., 2024 |
^CYP9A32|Spodoptera litura|abamectin|Liang et al., 2024|
^CYP9A68|Chilo suppressalis|methoxyfenozide|Guo et al., 2025|
^CYP9A157 (called CYP9A75a)|Spodoptera litura|cyantraniliprole, a-cypermethrin, nicotine  | Li et al., 2024|
^CYP9A158 (called CYP9A75b)|Spodoptera litura|cyantraniliprole, a-cypermethrin, nicotine  | Li et al., 2024|
^CYP9A186(F116V)|Spodoptera exigua|O(H.armigera) emamectin benzoate,abamectin (high R)| Li et al., 2023|
^CYP9A186(F116V)|Spodoptera exigua|emamectin benzoate,abamectin (low R)| Li et al., 2023|
^CYP9A186|Spodoptera exigua|O(Plutella xylostella) emamectin benzoate, abamectin |Wang et al., 2024|
^CYP9J11|Anopheles funestus|pyrethroids|Riveron et al., 2017|
^CYP9J28|Aedes aegypti|pyrethroids|Stevenson et al., 2012; Pavlidi et al.,2012; Samantsidis et al., 2020|
^CYP9K1(G454A)|Anopheles funestus|more R than wt 9K1: deltamethrin, cypermethrin, permethrin|Djoko et al.,2025|
^CYP9Q1|Apis mellifera|thiacloprid|Manjon et al.2018|
^CYP9Q2|Apis mellifera|thiacloprid|Manjon et al.2018| 
^CYP9Q2|Apis mellifera|flupyradifurone|Haas et al. 2021|
^CYP9Q2|Apis mellifera|chlorantraniliprole, NOT flubendiamide|Haas et al. 2022 | 
^CYP9Q2|Apis mellifera|coumaphos, coumaphos oxon|Xiao et al. 2024 | 
^CYP9Q3|Apis mellifera|thiacloprid|Manjon et al.2018|
^CYP9Q3|Apis mellifera|flupyradifurone|Haas et al. 2021|
^CYP9Q3|Apis mellifera|chlorantraniliprole, NOT flubendiamide|Haas et al. 2022 |
^CYP9Q3|Apis mellifera|coumaphos, coumaphos oxon|Xiao et al. 2024 |
^CYP9Q4|Bombus terrestris|thiacloprid|Manjon et al.2018|  
^CYP9Q5|Bombus terrestris|thiacloprid|Manjon et al.2018| 
^CYP9Q6|Bombus terrestris|thiacloprid, acetamiprid|Troczka et al.,2019| 
^CYP9R38|Osmia bicornis|thiacloprid|Beadle et al., 2019|
^CYP9BU1|Osmia bicornis|thiacloprid, NOT imidacloprid|Beadle et al., 2019| 
^CYP9BU2|Osmia bicornis|NOT thiacloprid or imidacloprid|Beadle et al., 2019| 
^CYP321A7|Spodoptera frugiperda|λ-cyhalothrin|Li et al.,2024|
^CYP321A8|Spodoptera frugiperda|O:(Fall armyworm) deltamethrin|Chen and Palli 2021|
^CYP321A9|Spodoptera frugiperda|gramin, tricin|He et al., 2023|
^CYP321A16|Spodoptera exigua|chlorpyrifos|Hu et al., 2020| 
^CYP321A19|Spodoptera litura|indoxacarb,chlorantraniliprole,λ-cyhalothrin,imidacloprid NOT chlorpyrifos|Li et al., 2023|
^CYP321F3|Chilo suppressalis|methoxyfenozide|Guo et al., 2025|
^CYP324A12|Chilo suppressalis|lethality at 2nd larval instar|Guo et al., 2025|
^CYP332A1|Spodoptera exigua|chlorpyrifos|Hu et al., 2020|
^CYP332A1|Spodoptera litura|cyantraniliprole (by feeding, not topical)|Li et al., 2023|
^CYP337B3|Helicoverpa armigera |fenvalerate|cited in McLeman et al., 2020|
^CYP402C1|Bemisia tabaci|imidacloprid|Guo et al., 2022|
^[[cyp_clans|CYP4 clan]]||||   
^CYP4D24|Aedes aegypti|permethrin|Reid et al., 2014| 
^CYP4G15|Aphis gossypii|cyantraniliprole|Ding et al. 2023|
^CYP4H29|Aedes aegypti|permethrin|Reid et al., 2014| 
^CYP4H33|Aedes aegypti|permethrin|Reid et al., 2014|  
^CYP4J15v1|Aedes aegypti|permethrin|Reid et al., 2014|
^CYP4S9|Spodoptera litura|abamectin|Liang et al., 2024| 
^CYP4S24|Musca domestica|permethrin|Li et al., 2023|
^CYP4CJ1|Aphis gossypii|cyantraniliprole|Zeng et al. 2021|
^CYP4CK1|Aphis gossypii|thiamethoxam|Lv et al. 2022|
^CYP4CK1|Aphis gossypii|cyantraniliprole|Ding et al. 2023|
^CYP4CL2|Panonychus citri| pyridaben| Pan et al., 2023|
^CYP4CS5|Bemisia tabaci|thiamethoxam, clothianidin| Hu et al., 2024|
^CYP4FB1|Laodelphax striatellus|deltamethrin, fenvalerate, etofenprox|Yu et al., 2023|
^CYP340G2|Spodoptera litura|indoxacarb,chlorantraniliprole,λ-cyhalothrin,imidacloprid NOT chlorpyrifos,λ-cyhalothrin|Li et al., 2023| 
^CYP380C6|Aphis gossypii|spirotetramat|Pan et al. 2018| 
^CYP380C6|Aphis gossypii|cyantraniliprole, a-cypermethrin|Zeng et al. 2021| 
^CYP380C40|Myzus persicae|sulfoxaflor|Pym et al., 2022|
^CYP340L25 (called 340L)|Spodoptera litura|no effect on cyantraniliprole tox|Li et al., 2023|
^CYP340AX8 (called 340A)|Spodoptera litura|cyantraniliprole|Li et al., 2023| 
^CYP439A1|Laodelphax striatellus|NOT fenvalerate|Yu et al., 2023| 
^[[cyp_clans|Mito clan]]||||  
^CYP12A4|Drosophila melanogaster|(OE) lufenuron|Bogwitz et al., 2005|  
^CYP12A5|Drosophila melanogaster|(OE) nitenpyram (activation)|Harrop et al. 2018|
^CYP12D1|Drosophila melanogaster|(OE) DDT, dicyclanil|Daborn et al. 2007|
^CYP12D1|Drosophila melanogaster|(OE) malathion|Battlay et al. 2018| 
^CYP301B1|Laodelphax striatellus|deltamethrin, fenvalerate, etofenprox|Yu et al., 2023|
^CYP339A1|Spodoptera litura|indoxacarb,chlorantraniliprole,λ-cyhalothrin,imidacloprid NOT chlorpyrifos|Li et al., 2023|
^CYP419A1|Nilaparvata lugens|ethiprole|Zeng et al., 2025|