Arthropod P450 Enchiridion

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in_vitro_activities [2025/11/19 16:37] – renefeyereisenin_vitro_activities [2025/12/23 17:27] (current) – renefeyereisen
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 <searchtable> <searchtable>
- 
-===== In vitro activities ===== 
- 
-key: 
-P: purified enzyme        
-E: E.coli expression      
-B: baculovirus expression                   
-D: Drosophila cell transfection                   
-Y: yeast expression      
-O: other expression system.  
-Negative results (i.e. no metabolism detected) are listed when available. 
  
 |^CYP^species^in vitro activity ^reference^ |^CYP^species^in vitro activity ^reference^
 ^**CYP2 clan**|||| ^**CYP2 clan**||||
 ^CYP2L1| Panulirus argus (spiny lobster)|O:(Pichia)progesterone, testosterone |Boyle et al., 1998| ^CYP2L1| Panulirus argus (spiny lobster)|O:(Pichia)progesterone, testosterone |Boyle et al., 1998|
-^[[cyp15|CYP15A1]]|Diploptera punctata|P: methyl farnesoate to JH III|Helvig et al. 2004a|+^[[cyp15|CYP15A1]]|Diploptera punctata|P: methyl farnesoate to R-JH III|Helvig et al. 2004a|
 ^[[cyp15|CYP15A1]]|Diploptera punctata|D: farnesoic acid to JH III |Jia et al. 2024| ^[[cyp15|CYP15A1]]|Diploptera punctata|D: farnesoic acid to JH III |Jia et al. 2024|
 ^CYP15A1|Tribolium castaneum|O: (Sf9 transfection) methyl farnesoate, farnesoic acid|Minakuchi et al., 2015| ^CYP15A1|Tribolium castaneum|O: (Sf9 transfection) methyl farnesoate, farnesoic acid|Minakuchi et al., 2015|
 ^CYP15A1|Apis mellifera|P: methyl farnesoate|Hou et al., 2023| ^CYP15A1|Apis mellifera|P: methyl farnesoate|Hou et al., 2023|
 +^CYP15A1|Scleroderma guani (parasitic wasp) |P:methyl farnesoate to S-JH III|Ouyang et al., 2025|
 ^CYP15C1|Bombyx mori|D: farnesoic acid 18x> methyl farnesoate|Daimon et al., 2012| ^CYP15C1|Bombyx mori|D: farnesoic acid 18x> methyl farnesoate|Daimon et al., 2012|
 ^CYP18A1|Drosophila melanogaster|D:20-hydroxyecdysone|Guittard et al., 2011| ^CYP18A1|Drosophila melanogaster|D:20-hydroxyecdysone|Guittard et al., 2011|
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 ^CYP3002B2|Varroa destructor|E:amitraz, flumethrin|Mavridis et al., 2025| ^CYP3002B2|Varroa destructor|E:amitraz, flumethrin|Mavridis et al., 2025|
 ^[[cnglc|CYP3201B1]]|Chamberlinius hualieniensis|Y: phenylacetonitrile|Yamaguchi et al. 2018| ^[[cnglc|CYP3201B1]]|Chamberlinius hualieniensis|Y: phenylacetonitrile|Yamaguchi et al. 2018|
 +^[[cnglc|CYP30008A2]]|Chamberlinius hualienensis|Y:4-hydroxyphenylacetaldoxime, indole-3-acetyldoxime|Yamaguchi & Asano, 2025)|
 ^**CYP3 clan**|||| ^**CYP3 clan**||||
 ^[[CYP6A1]]|Musca domestica|P: aldrin, heptachlor|Andersen et al., 1994| ^[[CYP6A1]]|Musca domestica|P: aldrin, heptachlor|Andersen et al., 1994|
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 ^CYP6M2|Anopheles gambiae|E: pyrethroids, DDT, bendiocarb, pyriproxyfen|Stevenson et al., 2011 Mitchell et al., 2012 Edi et al., 2014 Yunta et al., 2016; Yunta etal., 2019|  ^CYP6M2|Anopheles gambiae|E: pyrethroids, DDT, bendiocarb, pyriproxyfen|Stevenson et al., 2011 Mitchell et al., 2012 Edi et al., 2014 Yunta et al., 2016; Yunta etal., 2019| 
 ^CYP6M7|Anopheles funestus|E: pyrethroids|Riveron et al.,2014| ^CYP6M7|Anopheles funestus|E: pyrethroids|Riveron et al.,2014|
 +^CYP6J5|Anopheles gambiae|E:fluoranthene |Muhammad et al., 2025|
 ^CYP6P2|Anopheles gambiae|E: pyriproxyfen|Yunta et al., 2016| ^CYP6P2|Anopheles gambiae|E: pyriproxyfen|Yunta et al., 2016|
 ^CYP6P2|Anopheles gambiae|E: permethrin, etofenprox, deltamethrin; NOT bifenthrin, λ-cyhalothrin,cypermethrin|Yunta et al., 2019| ^CYP6P2|Anopheles gambiae|E: permethrin, etofenprox, deltamethrin; NOT bifenthrin, λ-cyhalothrin,cypermethrin|Yunta et al., 2019|
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 ^CYP6P3|Anopheles gambiae|E: chlorfenapyr|Yunta et al., 2023| ^CYP6P3|Anopheles gambiae|E: chlorfenapyr|Yunta et al., 2023|
 ^CYP6P3 E205D allele|Anopheles gambiae|E: permethrin, a-cypermethrin, deltamethrin|Kengne-Ouafo et al., 2024| ^CYP6P3 E205D allele|Anopheles gambiae|E: permethrin, a-cypermethrin, deltamethrin|Kengne-Ouafo et al., 2024|
 +^CYP6P3|Anopheles gambiae|E:fluorene |Muhammad et al., 2025|
 ^CYP6P4|Anopheles gambiae|E: permethrin, etofenprox, deltamethrin; NOT bifenthrin, λ-cyhalothrin,cypermethrin|Yunta et al., 2019|  ^CYP6P4|Anopheles gambiae|E: permethrin, etofenprox, deltamethrin; NOT bifenthrin, λ-cyhalothrin,cypermethrin|Yunta et al., 2019| 
 ^CYP6P4|Anopheles gambiae|E: pyriproxyfen|Yunta et al., 2019|  ^CYP6P4|Anopheles gambiae|E: pyriproxyfen|Yunta et al., 2019| 
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 ^CYP6P5|Anopheles gambiae|E: pyriproxyfen|Yunta et al., 2016|  ^CYP6P5|Anopheles gambiae|E: pyriproxyfen|Yunta et al., 2016| 
 ^CYP6P5|Anopheles gambiae|E: permethrin, etofenprox, deltamethrin; NOT bifenthrin, λ-cyhalothrin,cypermethrin|Yunta et al., 2019| ^CYP6P5|Anopheles gambiae|E: permethrin, etofenprox, deltamethrin; NOT bifenthrin, λ-cyhalothrin,cypermethrin|Yunta et al., 2019|
 +^CYP6P3|Anopheles gambiae|E:fluorene, fluoranthene |Muhammad et al., 2025|
 +^CYP6P5|Anopheles gambiae|E:fluorene, fluoranthene |Muhammad et al., 2025|
 ^CYP6P5|Anopheles albimanus|E: a-cypermethrin, deltamethrin|Kusimo et al. 2022|  ^CYP6P5|Anopheles albimanus|E: a-cypermethrin, deltamethrin|Kusimo et al. 2022| 
 ^CYP6P7|Anopheles minimus|B:permethrin, cypermethrin,deltamethrin, benzoyloxyresorufin, ethoxyresorufin, NOT bioallethrin, lambda-cyhalothin, chlorpyrifos, propoxur|Duangkaew et al. 2011| ^CYP6P7|Anopheles minimus|B:permethrin, cypermethrin,deltamethrin, benzoyloxyresorufin, ethoxyresorufin, NOT bioallethrin, lambda-cyhalothin, chlorpyrifos, propoxur|Duangkaew et al. 2011|
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 ^CYP6Z2|Anopheles gambiae|E: pyriproxyfen|Yunta et al., 2016| ^CYP6Z2|Anopheles gambiae|E: pyriproxyfen|Yunta et al., 2016|
 ^CYP6Z2|Anopheles gambiae|B: carbaryl|Chiu et al., 2008|   ^CYP6Z2|Anopheles gambiae|B: carbaryl|Chiu et al., 2008|  
-^CYP6Z2|Anopheles gambiae|Y: non-toxic esterase metabolites of pyr.|Chandor-Proust et al. 2013|  +^CYP6Z2|Anopheles gambiae|E: non-toxic esterase metabolites of pyr.|Chandor-Proust et al. 2013|  
-^CYP6Z8|Aedes aegypti|Y: non-toxic esterase metabolites of pyr.|Chandor-Proust et al. 2013| +^CYP6Z2|Anopheles gambiae|E:fluorene, fluoranthene |Muhammad et al., 2025| 
 +^CYP6Z3|Anopheles gambiae|E:fluorene, fluoranthene |Muhammad et al., 2025| 
 +^CYP6Z8|Aedes aegypti|Y: non-toxic esterase metabolites of pyr.,alkoxyresorufins, a-naphthoflavone, resveratrol,diethylstilbestrol pyriproxifen|Chandor-Proust et al. 2013| 
 ^CYP6AA1|Anopheles funestus|E: bendiocarb, pyrethroids|Ibrahim et al., 2018|  ^CYP6AA1|Anopheles funestus|E: bendiocarb, pyrethroids|Ibrahim et al., 2018| 
 ^CYP6AA3|Anopheles minimus|B: deltamethrin|Boonsuepsakul et al., 2008| ^CYP6AA3|Anopheles minimus|B: deltamethrin|Boonsuepsakul et al., 2008|
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 ^CYP6AE14|Helicoverpa armigera|Y: P-nitroanisole, ECOD, gossypol|Chen et al.,2019| ^CYP6AE14|Helicoverpa armigera|Y: P-nitroanisole, ECOD, gossypol|Chen et al.,2019|
 ^CYP6AE14|Helicoverpa armigera|B:2-tridecanone|Wang et al., 2018| ^CYP6AE14|Helicoverpa armigera|B:2-tridecanone|Wang et al., 2018|
-^CYP6AE15|Helicoverpa armigera|B: IMI|Shi et al., 2018| +^CYP6AE15|Helicoverpa armigera|B: IMI|Shi et al., 2018| 
 +^CYP6AE15|Helicoverpa armigera|Y: oripavine N-demethylation|Xue et al., 2026 | 
 ^CYP6AE16|Helicoverpa armigera|B: IMI, aldrin|Shi et al., 2018| ^CYP6AE16|Helicoverpa armigera|B: IMI, aldrin|Shi et al., 2018|
 ^CYP6AE17|Helicoverpa armigera|B: EC, BFC, IMI, aldrin|Shi et al., 2018| ^CYP6AE17|Helicoverpa armigera|B: EC, BFC, IMI, aldrin|Shi et al., 2018|
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 ^CYP6CM1vQ|Bemisia tabaci|E: aldrin|Shi et al., 2018| ^CYP6CM1vQ|Bemisia tabaci|E: aldrin|Shi et al., 2018|
 ^CYP6CM1vQ|Bemisia tabaci|Y: luciferin substrates, pymetrozine,imidacloprid, NOT six others |Li et al., 2023| ^CYP6CM1vQ|Bemisia tabaci|Y: luciferin substrates, pymetrozine,imidacloprid, NOT six others |Li et al., 2023|
 +^CYP6CM1vQ|Bemisia tabaci|E: various phenolic compounds as inhibitors of 7-ethoxycoumarin deethylation |Ioannou et al., 2026|
 ^CYP6CM1|Bemisia tabaci|B:pymetrozine|Nauen et al., 2013| ^CYP6CM1|Bemisia tabaci|B:pymetrozine|Nauen et al., 2013|
 ^CYP6CM1|Bemisia tabaci|E: pyriproxifen, NOT flonicamid|Nauen et al., 2015| ^CYP6CM1|Bemisia tabaci|E: pyriproxifen, NOT flonicamid|Nauen et al., 2015|
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 ^CYP9A3|Helicoverpa armigera |B:esfenvalerate|Shi et al. 2021|  ^CYP9A3|Helicoverpa armigera |B:esfenvalerate|Shi et al. 2021| 
 ^CYP9A9|Spodoptera exigua |B:esfenvalerate |Shi et al., 2023| ^CYP9A9|Spodoptera exigua |B:esfenvalerate |Shi et al., 2023|
 +^CYP9A9a (=mutant V40L,Q160H,T208A)|Spodoptera exigua |B:esfenvalerate (2x better than 9A9b)|Shi et al., 2025|
 +^CYP9A9b (=wt)|Spodoptera exigua |B:esfenvalerate |Shi et al., 2025|
 ^CYP9A10|Spodoptera exigua |B:imperatorin, esfenvalerate |Shi et al., 2023| ^CYP9A10|Spodoptera exigua |B:imperatorin, esfenvalerate |Shi et al., 2023|
 ^CYP9A11|Spodoptera exigua |B:imperatorin, esfenvalerate |Shi et al., 2023| ^CYP9A11|Spodoptera exigua |B:imperatorin, esfenvalerate |Shi et al., 2023|
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 ^CYP321A8|Spodoptera exigua|B:cypermethrin, deltamethrin, chlorpyrifos|Hu et al. 2021| ^CYP321A8|Spodoptera exigua|B:cypermethrin, deltamethrin, chlorpyrifos|Hu et al. 2021|
 ^CYP321A8|Spodoptera frugiperda|P:chlorpyrifos, deltamethrin, chloranthraniliprole| Chen et al., 2024|   ^CYP321A8|Spodoptera frugiperda|P:chlorpyrifos, deltamethrin, chloranthraniliprole| Chen et al., 2024|  
 +^CYP321A9|Spodoptera frugiperda|P:chlorantraniliprole, tetrachlorantraniliprole|Cao et al., 2026|
 ^CYP321A19 aka CYP321A16|Spodoptera exigua|B:chlorpyrifos|Hu et al., 2020| ^CYP321A19 aka CYP321A16|Spodoptera exigua|B:chlorpyrifos|Hu et al., 2020|
 ^CYP321A19|Spodoptera litura|B:indoxacarb, DCJW|Li et al., 2023| ^CYP321A19|Spodoptera litura|B:indoxacarb, DCJW|Li et al., 2023|
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 ^CYP4CE1|Nilaparvata lugens|B: nitenpyram, imidacloprid NOT tricin, hesperetin, proquamezine, etofenprox|Zhang et al., 2025|  ^CYP4CE1|Nilaparvata lugens|B: nitenpyram, imidacloprid NOT tricin, hesperetin, proquamezine, etofenprox|Zhang et al., 2025| 
 ^CYP4CE2|Laodelphax stritellus|P: imidacloprid, nitenpyram|Teng et al., 2025|  ^CYP4CE2|Laodelphax stritellus|P: imidacloprid, nitenpyram|Teng et al., 2025| 
-^CYP4FB1|Laodelphax striatellus|B: p-nitroanisole, 7-ethoxycoumarin |Yu et al. 2023 |   +^CYP4FB1|Laodelphax striatellus|B: p-nitroanisole, 7-ethoxycoumarin |Yu et al. 2023 | 
 +^[[cnglc|CYP4GL4]]|Chamberlinius hualienensis|Y:4-hydroxyphenylacetaldoxime, indole-3-acetyldoxime|Yamaguchi & Asano, 2025)|   
 ^CYP325A ?|Anopheles funestus|E: pyrethroids|Wamba et al., 2021| ^CYP325A ?|Anopheles funestus|E: pyrethroids|Wamba et al., 2021|
 ^CYP340G2|Spodoptera litura|B:indoxacarb, DCJW|Li et al., 2023|   ^CYP340G2|Spodoptera litura|B:indoxacarb, DCJW|Li et al., 2023|  
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 ^CYP389C16|Tetranychus cinnabarinus|E: cyflumetofen, pyridaben, AB-1|Feng et al., 2020|  ^CYP389C16|Tetranychus cinnabarinus|E: cyflumetofen, pyridaben, AB-1|Feng et al., 2020| 
 ^[[cnglc|CYP405A2]]|Zygaena filipendula|Y:Val/Ile to their aldoximes |Jensen et al., 2011| ^[[cnglc|CYP405A2]]|Zygaena filipendula|Y:Val/Ile to their aldoximes |Jensen et al., 2011|
-^CYP417A2v2|Laodelphax striatellus|B:imidacloprid,p-nitroanisole, 7EC |Miah et al. 2017|  +^CYP417A2v2|Laodelphax striatellus|B:imidacloprid,p-nitroanisole, 7EC |Miah et al. 2017|  
 +^CYP425A1|Nilaparvata lugens|B: etofenprox to 2-(4-ethoxyphenyl)-2-methylpropyl 3-phenoxybenzoate (ester metabolite) |Zhang et al., 2026| 
 ^CYP439A1v3|Laodelphax striatellus|B: deltamethrin, p-nitroanisole, EC, ER, reports negatives|Miah et al. 2019|  ^CYP439A1v3|Laodelphax striatellus|B: deltamethrin, p-nitroanisole, EC, ER, reports negatives|Miah et al. 2019| 
 ^CYP439A1|Nilaparvata lugens|buprofezin|Zeng et al.2023| ^CYP439A1|Nilaparvata lugens|buprofezin|Zeng et al.2023|
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 ^CYP339A1|Helicoverpa armigera|B: esfenvalerate|Shi et al. 2022|  ^CYP339A1|Helicoverpa armigera|B: esfenvalerate|Shi et al. 2022| 
 ^CYP339A1|Spodoptera litura|B:indoxacarb, DCJW|Li et al., 2023| ^CYP339A1|Spodoptera litura|B:indoxacarb, DCJW|Li et al., 2023|
-^CYP353D1v2|Laodelphax striatellus|B: buprofezin, imidacloprid, p-nitroanisole|Elzaki et al., 2017a,b| +^CYP353D1v2|Laodelphax striatellus|B: buprofezin, imidacloprid, p-nitroanisole|Elzaki et al., 2017a,b|  
 </searchtable> </searchtable>
in_vitro_activities.txt · Last modified: by renefeyereisen