Arthropod P450 Dokuwiki

In vitro activities

key: P: purified enzyme E: E.coli expression B: baculovirus expression D: Drosophila cell transfection Y: yeast expression O: other expression system.

Negative results (i.e. no metabolism detected) are listed when available. These are indicative only, because improvements in assay systems can turn a negative result (e.g. metabolism below the limit of detection) to a positive one. Positive results also need to be interpreted with caution.

CYP	species	in vitro activity	reference
CYP2 clan
CYP15A1	Diploptera punctata	P: methyl farnesoate	Helvig et al. 2004a
CYP15A1	Tribolium castaneum	O: (Sf9 transfection) methyl farnesoate, farnesoic acid	Minakuchi et al., 2015
CYP15A1	Apis mellifera	P: methyl farnesoate	Hou et al., 2023
CYP15C1	Bombyx mori	D: farnesoic acid 18x> methyl farnesoate	Daimon et al., 2012
CYP18A1	Drosophila melanogaster	D:20-hydroxyecdysone	Guittard et al., 2011
CYP18A1	Helicoverpa armigera	B: ethoxycoumarin, aldrin	Shi et al. 2022
CYP18B1	Helicoverpa armigera	B: BOMR	Shi et al. 2022
CYP303A1	Helicoverpa armigera	B:BOMR, 2-tridecanone	Shi et al. 2022
CYP304F1	Helicoverpa armigera	B: BOMR	Shi et al. 2022
CYP305B1	Helicoverpa armigera	B: aldrin, esfenvalerate	Shi et al. 2022
CYP305D1	Apis mellifera	E: NOT imidacloprid or thiacloprid	Alptekin et al., 2016
CYP306A1	Drosophila melanogaster	D: 2,22,25-trideoxyecdysone	Warren et al., 2004
CYP306A1	Bombyx mori	D: 2,22,25-trideoxyecdysone	Niwa et al., 2004
CYP306A1	Mamestra brassicae	D: 2,22,25-trideoxyecdysone	Ogihara et al. 2017
CYP306A1	Helicoverpa armigera	B: ethoxycoumarin, BOMR	Shi et al. 2022
CYP306A2 (2?)	Nilaparvata lugens	D: ketodiol>ketotriol	Zhou et al. 2020
CYP307A2 (wrongly called 307A1)	Helicoverpa armigera	B: BOMR	Shi et al. 2022
CYP392A1	Tetranychus cinnabarius	E: cyflumetofen	Feng et al., 2023
CYP392A1	Tetranychus urticae	E: NOT amitraz, NOT chlorfenapyr	Vandenhole et al., 2024
CYP392A11	Tetranychus urticae	E: cyenopyrafen, fenpyroximate, EC, luciferin-ME-EGE	Riga et al., 2015
CYP392A11	Tetranychus urticae	E: NOT amitraz, NOT chlorfenapyr	Vandenhole et al., 2024
CYP392A11	Tetranychus urticae	E:bifenazate, cyenopyrafen fenpyroximate, carbaryl, pyflubumide,chlorpyrifos, 7EC, 7EFC	Tsakireli et al., 2024
CYP392A16	Tetranychus urticae	E: abamectin, pyflubumide carboxamide, luciferin-ME-EGE NOT hexythiazox, clofentezine, bifenthrin	Riga et al., 2014; Fotoukkiaii et al., 2021
CYP392A16	Tetranychus urticae	E: amitraz, NOT chlorfenapyr	Vandenhole et al., 2024
CYP392A16	Tetranychus urticae	E:abamectin, amitraz,etoxazole, carbaryl, pyflubumide,chlorpyrifos, 7EMC, 7EFC, 7EC	Tsakireli et al., 2024
CYP392D2	Tetranychus urticae	E:etoxazole,chlorpyrifos,pyridaben, fenproximate, 7EMC, 7EFC, 7EC	Tsakireli et al., 2024
CYP392D8	Tetranychus urticae	NOT abamectin	Xu et al., 2023
CYP392D8	Tetranychus urticae	E: chlorfenapyr, NOT amitraz	Vandenhole et al., 2024
CYP392D8	Tetranychus urticae	E:chlorfenapyr,tebufenpyrad,fenazyquin, carbaryl, 7EMC, 7EC	Tsakireli et al., 2024
CYP392E7	Tetranychus urticae	E: NOT spirodiclofen	Demaeght et al., 2013
CYP392E10	Tetranychus urticae	E & B: spirodiclofen, spiromesifen, NOT spirotetramat	Demaeght et al., 2013
CYP392E10	Tetranychus urticae	E: NOT amitraz, NOT chlorfenapyr	Vandenhole et al., 2024
CYP3201B1	Chamberlinius hualieniensis	Y: phenylacetonitrile	Yamaguchi et al. 2018
CYP3 clan
CYP6A1	Musca domestica	P: aldrin, heptachlor	Andersen et al., 1994
CYP6A1	Musca domestica	P: sesquiterpenoids	Andersen et al., 1997
CYP6A1	Musca domestica	P: testosterone, progesterone,androstenedione	Jacobsen et al., 2006 Murataliev et al., 2008
CYP6A1	Musca domestica	P: 7-propoxycoumarin, 1-bromochlordene, chlordene, 1-hydroxychlordene, isodrin, pisatin, chlorfenapyr	rev Feyereisen, 2005
CYP6A1	Musca domestica	P: diazinon	Sabourault et al. 2001
CYP6A2	Drosophila melanogaster	Y:aflatoxinB1,7,12-dimethylbenz[a]anthracene,3-amino-1- methyl-5H-pyrido[4,3-b]-indole	Saner et al., 1996
CYP6A2	Drosophila melanogaster	B: aldrin, heptachlor, diazinon	Dunkov et al. 1997
CYP6A5	Musca domestica	P: benzphetamine, p-chloro-N-methylaniline, methoxyresorufin	rev Feyereisen, 2005
CYP6A8	Drosophila melanogaster	Y: lauric acid, aldrin	Helvig et al. 2004b
CYP6A8	Drosophila melanogaster	P: lauric acid, capric acid	Lee et al. 2022
CYP6A36	Musca domestica	B: permethrin, ethoxycoumarin	Li et al., 2023
CYP6A51	Ceratitis capitata	E: λ-cyhalothrin, deltamethrin NOT spinosad, malathion	Tsakireli et al. 2019
CYP6A61	Bactrocera oleae	E:a-cypermethrin	Kampouraki et al., 2023
CYP6B1	Papilio polyxenes	B: furanocoumarins, a-naphthoflavone, flavone, coumarin,diazinon	Ma et al., 1994, Hung et al., 1997, Wen et al., 2003 Li et al., 2004 Wen et al.,2005
CYP6B1	Papilio polyxenes	B: xanthotoxin	Wang et al, 2018
CYP6B2	Helicoverpa armigera	B:esfenvalerate	Shi et al. 2021
CYP6B3	Papilio polyxenes	B: furanocoumarins, a-naphthoflavone	Wen et al., 2006
CYP6B4	Papilio glaucus	B: furanocoumarins, ethoxycoumarin	Hung et al., 1997, Li et al., 2003
CYP6B6	Helicoverpa armigera	P: ethoxycoumarin	Liu et al., 2013
CYP6B6	Helicoverpa armigera	E: esfenvalerate	Tian et al., 2017
CYP6B6	Helicoverpa armigera	E: capsaicin	Tian et al., 2019
CYP6B6	Helicoverpa armigera	B:esfenvalerate	Shi et al. 2021
CYP6B6	Helicoverpa armigera	E: capsaicin, dehydrocapsaicin	Xiong et al., 2025
CYP6B6	Helicoverpa assulta	E: diazinon, malathion, phoxim,propoxur,esfenvalerate, NOT several others	Xiong et al., 2024
CYP6B6	Helicoverpa assulta	E: capsaicin, dehydrocapsaicin	Xiong et al., 2025
CYP6B7	Helicoverpa armigera	O:Pichia. p-nitroanisole, ECOD, fenvalerate, bifenthrin, chlorpyrifos	Zhao et al., 2017, 2018
CYP6B7	Helicoverpa armigera	B:esfenvalerate	Shi et al. 2021
CYP6B8	Helicoverpa zea	B: chlorogenic acid, quercetin, rutin, xanthotoxin, flavone, indole-3-carbinol, a-cypermethrin, carbaryl, diazinon, aldrin	Li et al. 2004; Wen et al., 2009; Hopkins et al. 2010?
CYP6B17	Papilio glaucus	B: furanocoumarins, ethoxycoumarin	Li et al., 2003
CYP6B21	Papilio glaucus	B: furanocoumarins, ethoxycoumarin	Li et al., 2003
CYP6B25	Papilio canadensis	B: furanocoumarins	Li et al., 2003
CYP6B26	Papilio canadensis	B: NOT furanocoumarins	Li et al., 2003
CYP6B27	Helicoverpa zea	B: aldrin, diazinon, carbaryl, a-cypermethrin	Wen et al. 2009
CYP6B33	Papilio multicaudatus	B: furanocoumarins	Mao et al., 2007
CYP6B43	Helicoverpa armigera	B: NOT esfenvalerate	Shi et al. 2021
CYP6B89 (called GP04)	Galleria mellonella	Y(Pichia):polyethylene	Son et al., 2024
CYP6D1	Musca domestica	Y: methoxyresorufin	Smith and Scott 1997
CYP6D10	Musca domestica	B: permethrin, ethoxycoumarin	Li et al., 2023
CYP6G1	Drosophila melanogaster	O: imidacloprid, DDT, methoxychlor	Joussen et al., 2008, 2010
CYP6G1	Drosophila melanogaster	D: five neonicotinoids, “N-sulfoxaflor”, NOT sulfoxaflor or “chlorosulfoxaflor”	Sparks et al.2012
CYP6G1	Drosophila melanogaster	P: p-nitroanisole, pNAOD inhibition by many compounds	Cheesman et al.2013
CYP6G3	Lucilia cuprina	E: p-nitroanisole, EC, imidacloprid, diazinon	Traylor et al., 2017
CYP6G4	Musca domestica	E: propoxur	Zhu et al., 2022
CYP6G4	Musca domestica	E: chlorpyrifos, tetramethrin,methomyl, imidacloprid, acetamiprid, NOT permethrin	Zhu et al., 2023
CYP6G6	Bactrocera oleae	E: deltamethrin	Kampouraki et al., 2023
CYP6G28	Bactrocera oleae	E:deltamethrin	Kampouraki et al., 2023
CYP6M2	Anopheles gambiae	E: pyrethroids, DDT, bendiocarb, pyriproxyfen	Stevenson et al., 2011 Mitchell et al., 2012 Edi et al., 2014 Yunta et al., 2016; Yunta etal., 2019
CYP6M7	Anopheles funestus	E: pyrethroids	Riveron et al.,2014
CYP6P2	Anopheles gambiae	E: pyriproxyfen	Yunta et al., 2016
CYP6P2	Anopheles gambiae	E: permethrin, etofenprox, deltamethrin; NOT bifenthrin, λ-cyhalothrin,cypermethrin	Yunta et al., 2019
CYP6P3	Anopheles gambiae	E: pyrethroids, bendiocarb , pyriproxyfen,resorufins, luciferins	Muller et al., 2008 Stevenson, 2012 Edi et al., 2014 Yunta et al., 2016 Yunta et al., 2019
CYP6P3	Anopheles gambiae	E: chlorfenapyr	Yunta et al., 2023
CYP6P3 E205D allele	Anopheles gambiae	E: permethrin, a-cypermethrin, deltamethrin	Kengne-Ouafo et al., 2024
CYP6P4	Anopheles gambiae	E: permethrin, etofenprox, deltamethrin; NOT bifenthrin, λ-cyhalothrin,cypermethrin	Yunta et al., 2019
CYP6P4	Anopheles gambiae	E: pyriproxyfen	Yunta et al., 2019
CYP6P4	Anopheles arabiensis	E:permethrin and some but NOT all pyrethroids	Ibrahim et al., 2016
CYP6P4a Ghana, Mwi	Anopheles funestus	deltamethrin. a-cypermethrin	E:Tatchou-Nebangwa et al., 2024
CYP6P4b Ghana	Anopheles funestus	deltamethrin. a-cypermethrin	E:Tatchou-Nebangwa et al., 2024
CYP6P5	Anopheles gambiae	E: pyriproxyfen	Yunta et al., 2016
CYP6P5	Anopheles gambiae	E: permethrin, etofenprox, deltamethrin; NOT bifenthrin, λ-cyhalothrin,cypermethrin	Yunta et al., 2019
CYP6P5	Anopheles albimanus	E: a-cypermethrin, deltamethrin	Kusimo et al. 2022
CYP6P9a	Anopheles funestus	E:pyrethroids, O-dealkylations	Ibrahim et al.,2015, 2016; Yunta et al., 2019
CYP6P9a	Anopheles funestus	E:clothianidin, chlorfenapyr	Tchouakui et al., 2024
CYP6P9a	Anopheles funestus	E:permethrin,deltamethrin,a-cypermethrin,DDT,bendiocarb,chlorfenapyr,clothianidin	Ibrahim et al., 2024
CYP6P9b	Anopheles funestus	E: pyrethroids, O-dealkylation, NOT DDT	Riveron et al., 2013 Ibrahim et al.,2015, 2016
CYP6P9b	Anopheles funestus	E:clothianidin, chlorfenapyr	Tchouakui et al., 2024
CYP6P9b	Anopheles funestus	E:permethrin,deltamethrin,DDT,bendiocarb, chlorfenapyr,clothianidin	Ibrahim et al., 2024
CYP6P9b	Anopheles funestus	E: V301I variant better metabolizer of pyrethroids, and cleaves off the phenoybenzoyl ether	Nolte et al., 2022
CYP6P14	Culex quinquefasciatus	B: permethrin	Gong et al., 2022
CYP6Z1	Anopheles gambiae	B: DDT, carbaryl,	Chiu et al., 2008
CYP6Z1	Anopheles funestus	E:bendiocarb, pyrethroids	Ibrahim et al.,2016
CYP6Z2	Anopheles gambiae	E: alkoxyresorufins, resveratrol,entrodiol, butein,alpha-naphthoflavone, diltiazem,piceatannol,8-methoxypsoralen,testosterone	McLaughlin et al., 2008
CYP6Z2	Anopheles gambiae	E: pyriproxyfen	Yunta et al., 2016
CYP6Z2	Anopheles gambiae	B: carbaryl	Chiu et al., 2008
CYP6Z2	Anopheles gambiae	Y: non-toxic esterase metabolites of pyr.	Chandor-Proust et al. 2013
CYP6Z8	Aedes aegypti	Y: non-toxic esterase metabolites of pyr.	Chandor-Proust et al. 2013
CYP6AA1	Anopheles funestus	E: bendiocarb, pyrethroids	Ibrahim et al., 2018
CYP6AA3	Anopheles minimus	B: deltamethrin	Boonsuepsakul et al., 2008
CYP6AA3	Anopheles minimus	B: benzoyloxyresorufin	Sarapusit et al., 2013
CYP6AB3	Depressaria pastinacella	B: imperatorin	Mao et al., 2006
CYP6AB3v2	Depressaria pastinacella	B: imperatorin, myristicin	Mao et al., 2007, 2008
CYP6AB11	Amyelois transitella	B: imperatorin, piperonyl butoxide; NOT xanthotoxin, bergapten,angelicin, coumarin,flavone, a-naphthoflavone,quercetin. kaempferol,chlorogenic acid, myristicin, a-cypermethrin, aldrin,diazinon, aflatoxin B1	Niu et al., 2011
CYP6AB184 (called 13G08)	Galleria mellonella	Y(Pichia):polyethylene	Son et al., 2024
CYP6AE11	Helicoverpa armigera	B: EC, EFC, BFC, IMI, aldrin	Shi et al., 2018
CYP6AE11	Helicoverpa armigera	B: 2-tridecanone	Wang et al., 2018
CYP6AE12	Helicoverpa armigera	B: EC, IMI	Shi et al., 2018
CYP6AE14	Helicoverpa armigera	aldrin	Tao et al., 2012
CYP6AE14	Helicoverpa armigera	B: EC, EFC, BFC, IMI, aldrin	Shi et al., 2018
CYP6AE14	Helicoverpa armigera	Y: P-nitroanisole, ECOD, gossypol	Chen et al.,2019
CYP6AE14	Helicoverpa armigera	B:2-tridecanone	Wang et al., 2018
CYP6AE15	Helicoverpa armigera	B: IMI	Shi et al., 2018
CYP6AE16	Helicoverpa armigera	B: IMI, aldrin	Shi et al., 2018
CYP6AE17	Helicoverpa armigera	B: EC, BFC, IMI, aldrin	Shi et al., 2018
CYP6AE17	Helicoverpa armigera	B:indoxacarb	Wang et al., 2018
CYP6AE18	Helicoverpa armigera	B: EC, BFC, IMI, aldrin	Shi et al., 2018
CYP6AE18	Helicoverpa armigera	B:indoxacarb	Wang et al., 2018
CYP6AE19	Helicoverpa armigera	B: EC, EFC. MR, IMI, aldrin	Shi et al., 2018
CYP6AE19	Helicoverpa armigera	B:xanthotoxin, 2-tridecanone	Wang et al., 2018
CYP6AE20	Helicoverpa armigera	B: EC	Shi et al., 2018
CYP6AE24	Helicoverpa armigera	B: EC, IMI, aldrin	Shi et al., 2018
CYP6AE70	Spodoptera exigua	B: chlorpyrifos, cypermethrin, deltamethrin, 7EC	Hu et al., 2024
CYP6AE89	Depressaria pastinacella	P: bergapten, xanthotoxin, isopimpinellin, imperatorin, sphondin, angelicin	Calla et al. 2020
CYP6AQ1	Apis mellifera	B:flupyradifurone,7-benzyloxymethoxy-4-(trifluoromethyl)-coumarin (BOMFC)	Haas et al. 2021
CYP6AQ1	Apis mellifera	B: nicotine	Haas et al., 2023
CYP6AQ1	Apis mellifera	B: flupyradifurone, alkoxycoumarins	Xiao et al., 2023
CYP6AQ1 orthologs	8 neotropical bee species	B: flupyradifurone, alkoxycoumarins	Xiao et al., 2023
CYP6AQ1	Apis mellifera	B:coumaphos oxon, NOT coumaphos	Xiao et al.2024
CYP6AS1	Apis mellifera	B: quercetin, not kaempferol,eriodictyol,taxifolin	Mao et al., 2009
CYP6AS3	Apis mellifera	B: quercetin not kaempferol,eriodictyol,taxifolin	Mao et al., 2009
CYP6AS4	Apis mellifera	B: quercetin not kaempferol,eriodictyol,taxifolin	Mao et al., 2009
CYP6AS5	Apis mellifera	E: NOT imidacloprid or thiacloprid	Alptekin et al., 2016
CYP6AS10	Apis mellifera	B: quercetin not kaempferol,eriodictyol,taxifolin	Mao et al., 2009
CYP6AY1	Nilaparvata lugens	E:imidacloprid	Ding et al., 2013, Bao et al., 2016 Zhang et al., 2016
CYP6AY3v2	Laodelphax striatellus	B: imidacloprid	Wang et al., 2017
CYP6BB2	Anopheles gambiae	B: permethrin	Kasai et al., 2014
CYP6BD12	Nilaparvata lugens	E: chlorpyrifos	Zhang et al.2023
CYP6BE1	Apis mellifera	E: NOT imidacloprid or thiacloprid	Alptekin et al., 2016
CYP6BH5	Phaedon cochlaeriae	geraniol 8-hydroxylase (iridoid biosynthesis)	Fu et al., 2019
CYP6BQ9	Tribolium castaneum	B: deltamethrin, benzyloxyresorufin	Zhu et al., 2010
CYP6BQ23	Meligethes aeneus	B: deltamethrin,coumarins and resorufins	Zimmer et al., 2014
CYP6BQ23	Meligethes aeneus	B: deltamethrin, BOMFC	King et al., 2023
CYP6BQ25	Meligethes aeneus	B: deltamethrin, BOMFC	King et al., 2023
CYP6BU1	Osmia bicornis	B: thiacloprid, imidacloprid	Beadle et al., 2019
CYP6BU2	Osmia bicornis	B: thiacloprid, imidacloprid	Beadle et al., 2019
CYP6BW1	Dendroctonus ponderosae	B: diterpenes	Chiu et al. 2019
CYP6BW3	Dendroctonus ponderosae	B: diterpenes	Chiu et al. 2019
CYP6BZ2	Culex quinquefasciatus	B: permethrin, ehtoxycoumarin	Gong et al., 2022
CYP6CJ1	Pediculus humanus	B: ivermectin	Kim et al., 2018
CYP6CM1vQ	Bemisia tabaci	E: imidacloprid, alkoxycoumarins, resorufins	Karunker et al., 2009
CYP6CM1vQ	Bemisia tabaci	E: clothianidin, thiacloprid, NOT acetamiprid,thiamethoxam	Roditakis et al., 2011
CYP6CM1vQ	Bemisia tabaci	E: aldrin	Shi et al., 2018
CYP6CM1vQ	Bemisia tabaci	Y: luciferin substrates, pymetrozine,imidacloprid, NOT six others	Li et al., 2023
CYP6CM1	Bemisia tabaci	B:pymetrozine	Nauen et al., 2013
CYP6CM1	Bemisia tabaci	E: pyriproxifen, NOT flonicamid	Nauen et al., 2015
CYP6CM1	Bemisia tabaci	B,D, imidacloprid, clothianidin NOT dinetofuran	Hamada et al. 2019
CYP6CR1	Dendroctonus ponderosae	B:(Z)-6-nonen-2-one	Song et al., 2014
CYP6CS3	Sogatella furcifera	E: pymetrozine	Gong et al., 2023
CYP6CV5	Chilo suppressalis	B:chlorantraniliprole, MR, EC, EFC, BFC	Xu et al., 2024
CYP6CW1	Nilaparvata lugens	E: imidacloprid	Zhang et al., 2016
CYP6CX3	Bemisia tabaci	B:cyantraniliprole	Zhang et al., 2022
CYP6CY3	Myzus persicae nicotianae	B: nicotine, imidacloprid, clothianidin	Bass et al., 2013
CYP6CY3	Myzus persicae	D: imidacloprid, acetamiprid, clothianidin, thiacloprid,NOT dinetofuran	Nakao et al., 2019
CYP6CY3	Myzus persicae nicotianae	B: nicotine	Singh et al., 2020
CYP6CY4	Myzus persicae nicotianae	B: nicotine	Singh et al., 2020
CYP6CY12	Acyrthosiphon pisum	B: deltamethrin	Müller et al., 2023
CYP6CY13	Aphis gossypii	D: neonicotinoids, NOT sulfoxaflor	Hirata et al., 2017
CYP6CY22	Aphis gossypii	D: neonicotinoids, NOT sulfoxaflor	Hirata et al., 2017
CYP6DB3	Bemisia tabaci Q	B: imidacloprid	Wei et al., 2023
CYP6DE1	Dendroctonus ponderosae	B: a-pinene > t-verbenol	Chiu et al., 2019a
CYP6DE3	Dendroctonus ponderosae	B:(+)-α-pinene and other monoterpenes, but NOT exo-brevicomin precursors (Z)-dec-7-enal or (Z)-3-nonene	Nadeau et al., 2017
CYP6DJ1	Dendroctonus ponderosae	B: monoterpenes	Chiu et al. 2019b
CYP6DW3	Bemisia tabaci	B: imidacloprid	Xue et al., 2023
CYP6EM1	Bemisia tabaci	B:dinetofuran	Huang et al., 2024
CYP6ER1	Nilaparvata lugens	E:imidacloprid	Bao et al., 2016
CYP6ER1	Nilaparvata lugens	E: imidacloprid	Zhang et al., 2016
CYP6ER1	Nilaparvata lugens	B: nitenpyram, imidacloprid	Zhang et al., 2024
CYP6ER1 variants	Nilaparvata lugens	B:imidacloprid, flupyradifurone,not dinetofuran, not sulfoxaflor	Hamada et al., 2020
CYP6ER1	Nilaparvata lugens	P: imidacloprid,acetamiprid, nitenpyram	Zhang et al., 2023
CYP6ER1	Nilaparvata lugens	B: nitenpyram, imidacloprid NOT tricin, hesperetin, proquamezine, etofenprox	Zhang et al., 2024
CYP6FJ3	Sogatella furcifera	E: NOT pymetrozine	Gong et al., 2023
CYP6FD1	Locusta migratoria	B:deltamethrin, luciferin-Me, 7EC, NOT others	Liu et al. 2019
CYP6FE1	Locusta migratoria	B: imidacloprid	Liu et al., 2023
CYP6FJ3	Sogatella furcifera	E: triflumezopyrim	Gong et al., 2022
CYP6FJ3	Sogatella furcifera	E: pymetrozine	Gong et al., 2023
CYP6FU1	Laodelphax striatellus	B: deltamethrin	Elzaki et al., 2017
CYP9A3	Helicoverpa armigera	B:esfenvalerate	Shi et al. 2021
CYP9A9	Spodoptera exigua	B:esfenvalerate	Shi et al., 2023
CYP9A10	Spodoptera exigua	B:imperatorin, esfenvalerate	Shi et al., 2023
CYP9A11	Spodoptera exigua	B:imperatorin, esfenvalerate	Shi et al., 2023
CYP9A12 (17)	Helicoverpa armigera	Y: p-nitroanisole, methoxyresorufin,esfenvalerate	Yang et al., 2008
CYP9A12(17)	Helicoverpa armigera	Y: P-nitroanisole, ECOD, gossypol	Chen et al.,2019
CYP9A12 (17)	Helicoverpa armigera	E: capsaicin	Tian et al., 2019
CYP9A12 (17)	Helicoverpa armigera	B:esfenvalerate	Shi et al. 2021
CYP9A12 (17)	Helicoverpa armigera	E:psoralen, xanthotoxin, NOT angelicin or imperatorin	Tian et al., 2024
CYP9A17 (12)	Helicoverpa armigera	E: capsaicin	Tian et al., 2019
CYP9A17 (12)	Helicoverpa armigera	E: bioallethrin, bioresmethrin, esfenvalerate, cypermethrin, deltamethrin, permethrin	Tian et al., 2021
CYP9A17 (12)	Helicoverpa armigera	E:psoralen, xanthotoxin, NOT angelicin, or imperatorin	Tian et al., 2024
CYP9A14	Helicoverpa armigera	Y: p-nitroanisole, methoxyresorufin,esfenvalerate	Yang et al., 2008
CYP9A14	Helicoverpa armigera	E: MROD, EROD, BROD	Liu et al., 2014
CYP9A14	Helicoverpa armigera	E: capsaicin	Tian et al., 2019
CYP9A14	Helicoverpa armigera	B:esfenvalerate	Shi et al. 2021
CYP9A14	Helicoverpa armigera	E: bioallethrin, bioresmethrin, esfenvalerate, cypermethrin, deltamethrin, permethrin	Tian et al., 2021
CYP9A14	Helicoverpa armigera	E:psoralen, xanthotoxin, NOT angelicin or imperatorin	Tian et al., 2024
CYP9A15	Helicoverpa armigera	B:esfenvalerate	Shi et al. 2021
CYP9A16	Helicoverpa armigera	B:esfenvalerate	Shi et al. 2021
CYP9A23	Helicoverpa armigera	B:esfenvalerate	Shi et al. 2021
CYP9A24	Spodoptera frugiperda	B: xanthotoxin, indoxacarb	Shi et al., 2023
CYP9A25	Spodoptera frugiperda	B: esfenvalerate, indoxacarb	Shi et al., 2023
CYP9A25-F116I	Spodoptera litura	B: emamectin benzoate	Shi et al., 2024
CYP9A26	Spodoptera frugiperda	B: esfenvalerate, abamectin	Shi et al., 2023
CYP9A27	Spodoptera exigua	B: esfenvalerate	Shi et al., 2023
CYP9A27	Spodoptera frugiperda	B: esfenvalerate, abamectin	Shi et al., 2023
CYP9A28	Spodoptera frugiperda	B: xanthotoxin, esfenvalerate	Shi et al., 2023
CYP9A29	Spodoptera frugiperda	B: xanthotoxin,esfenvalerate, indoxacarb	Shi et al., 2023
CYP9A30	Spodoptera exigua	B: esfenvalerate, imperatorin	Shi et al., 2023
CYP9A30	Spodoptera frugiperda	B: BFC, BOMC	Amezian et al., 2022
CYP9A30	Spodoptera frugiperda	B: esfenvalerate	Shi et al., 2023
CYP9A31	Spodoptera frugiperda	B: BFC, BOMC, EFC, EC	Amezian et al., 2022
CYP9A31	Spodoptera frugiperda	B: indoxacarb	Shi et al., 2023
CYP9A32	Spodoptera frugiperda	B: BFC, BOMC	Amezian et al., 2022
CYP9A32	Spodoptera frugiperda	B: esfenvalerate, abamectin, indoxacarb	Shi et al., 2023
CYP9A40	Spodoptera exigua	B: esfenvalerate, abamectin,imperatorin	Shi et al., 2023
CYP9A40	Spodoptera exigua	B: chlorantraniliprole, alkoxycoumarins	Han et al., 2024
CYP9A58	Spodoptera frugiperda	B: esfenvalerate	Shi et al., 2023
CYP9A59	Spodoptera frugiperda	B: esfenvalerate, indoxacarb	Shi et al., 2023
CYP9A61	Cydia pomonella	E & O:Pichia	p-nitroanisole; activity inhibited by cypermethrin,permethrin, λ-cyhalothrin	Yang et al., 2017
CYP9A68	Chilo suppressalis	B:chlorantraniliprole, MR, EC, EFC, BFC	Xu et al., 2024
CYP9A75	Spodoptera frugiperda	B: esfenvalerate	Shi et al., 2023
CYP9A77	Spodoptera frugiperda	B: esfenvalerate, indoxacarb	Shi et al., 2023
CYP9A98	Spodoptera exigua	B: imperatorin	Shi et al., 2023
CYP9A107	Spodoptera exigua	B: esfenvalerate,imperatorin	Shi et al., 2023
CYP9A120	Cydia pomonella	B: λ-cyhalothrin	Li et al., 2022
CYP9A121	Cydia pomonella	B: λ-cyhalothrin	Li et al., 2022
CYP9A186	Spodoptera exigua	B: esfenvalerate, imperatorin	Shi et al., 2023
CYP9A187	Spodoptera exigua	B: esfenvalerate, imperatorin	Shi et al., 2023
CYP9A186-F116V	Spodoptera exigua	B: emamectin benzoate, abamectin, 7-benzyloxy-4-trifluoromethyl coumarin= BFCOD	Zuo et al. 2021
CYP9A187	Spodoptera exigua	B: NOT esfenvalerate, imperatorin or abamectin	Shi et al., 2023
CYP9A120	Cydia pomonella	B: λ-cyhalothrin, BMOR, BFC	Li et al., 2022 Bioxrviv
CYP9A121	Cydia pomonella	B: λ-cyhalothrin, BMOR, BFC	Li et al., 2022 Bioxrviv
CYP9A122	Cydia pomonella	B: λ-cyhalothrin, BMOR, BFC	Li et al., 2022 Bioxrviv
CYP9E1	Diploptera punctata	P: sequiterpenoids	rev Feyereisen, 2005
CYP9J5	Anopheles gambiae	E: pyriproxyfen	Yunta et al., 2016
CYP9J5	Anopheles gambiae	E: permethrin, etofenprox, deltamethrin; NOT bifenthrin, λ-cyhalothrin,cypermethrin	Yunta et al., 2019
CYP9J5	Anopheles gambiae	E: chlorfenapyr	Yunta et al., 2023
CYP9J11	Anopheles funestus	E: permethrin,deltamethrin, bendiocarb	Riveron et al., 2017
CYP9J24	Aedes aegypti	E: permethrin,deltamethrin	Stevenson et al., 2012
CYP9J26	Aedes aegypti	E: permethrin,deltamethrin	Stevenson et al., 2012
CYP9J28	Aedes aegypti	E: pyrethroids	Stevenson et al., 2012 Pavlidi et al.,2012
CYP9J32	Aedes aegypti	permethrin,deltamethrin, resorufins,luciferins	Stevenson et al., 2012
CYP9J32	Aedes aegypti	chlorfenapyr	Yunta et al., 2023
CYP9J33	Culex quinquefasciatus	B: permethrin, ethoxycoumarin	Gong et al., 2022
CYP9J34	Culex quinquefasciatus	B: permethrin, ethoxycoumarin	Gong et al., 2022
CYP9J34	Culex pipiens pallens	E: deltamethrin	Du et al., 2024
CYP9J40	Culex quinquefasciatus	B: permethrin, ethoxycoumarin	Gong et al., 2022
CYP9J45	Culex quinquefasciatus	B: permethrin, ethoxycoumarin	Gong et al., 2022
CYP9K1	Anopheles coluzzi	E: deltamethrin, NOT bendiocarb	Vontas et al. 2018
CYP9K1	Anopheles funestus	E: deltamethrin, DDT NOT permethrin	Hearn et al., 2022
CYP9K1-G454A	Anopheles funestus	E: deltamethrin (better than wt)	Djoko et al., 2025
CYP9K1	Anopheles gambiae	E: chlorfenapyr	Yunta et al., 2023
CYP9M6v2	Aedes aegypti	B: permethrin	Kasai et al., 2014
CYP9M6v2	Aedes aegypti	B: permethrin	Kasai et al., 2014
CYP9M10	Culex quinquefasciatus	E: permethrin	Wilding et al., 2012
CYP9Q1	Apis mellifera	B: tau-fluvalinate, coumaphos, quercetin	Mao et al.2011
CYP9Q1	Apis mellifera	B: nicotine	Haas et al., 2023
CYP9Q1	Apis mellifera	B:thiacloprid > imidacloprid	Manjon et al.2018
CYP9Q2	Apis mellifera	B:thiacloprid > imidacloprid	Manjon et al.2018
CYP9Q2	Apis mellifera	B: tau-fluvalinate, coumaphos	Mao et al.2011
CYP9Q2	Apis mellifera	B:flupyradifurone,7-benzyloxymethoxy-4-(trifluoromethyl)-coumarin (BOMFC)	Haas et al. 2021,
CYP9Q2	Apis mellifera	B:chlorantraniliprole	Haas et al.2022
CYP9Q2	Apis mellifera	B:coumaphos, coumaphos oxon	Xiao et al.2024
CYP9Q3	Apis mellifera	B: tau-fluvalinate, coumaphos, quercetin	Mao et al.2011
CYP9Q3	Apis mellifera	B:thiacloprid > imidacloprid	Manjon et al.2018
CYP9Q3	Apis mellifera	B:flupyradifurone,7-benzyloxymethoxy-4-(trifluoromethyl)-coumarin (BOMFC) 7-benzyloxy-4-(trifluoromethyl)- coumarin (BFC )	Haas et al. 2021, Haas and Nauen 2021
CYP9Q3	Apis mellifera	B:chlorantraniliprole	Haas et al.2022
CYP9Q3	Apis mellifera	B:coumaphos, NOT coumaphos oxon	Xiao et al.2024
CYP9Q4	Bombus terrestris	B:thiacloprid, imidacloprid	Manjon et al.2018
CYP9Q5	Bombus terrestris	B:thiacloprid, imidacloprid	Manjon et al.2018
CYP9Q6	Bombus terrestris	B:thiacloprid, acetamiprid	Troczka et al.,2019
CYP9Q orthologs	bees	B:thiacloprid, imidacloprid,flupyradifurone, alkylcoumarins	Haas et al.2022
CYP9T1	Ips confusus	B: myrcene	Sandstrom etal. 2008
CYP9T2	Ips pini	B: myrcene	Sandstrom et al. 2006
CYP9T2	Ips pini	B: myrcene, a-pinene, 3-carene, limonene not others	Song et al. 2013
CYP9T3	Ips pini	B: myrcene, a-pinene, 3-carene, limonene not others	Song et al. 2013
CYP9BU1	Osmia bicornis	B: imidacloprid, thiacloprid	Beadle et al. 2019
CYP9BU1	Osmia lignaria	B:thiacloprid, imidacloprid	Hayward et al., 2023
CYP9BU2	Osmia bicornis	B: thiacloprid > imidacloprid, alkoxycoumarins	Beadle et al. 2019
CYP9BU3	Chelostoma florisomme (Megachilidae)	B:thiacloprid > imidacloprid, 7MC, 7EC	Hayward et al., 2023
CYP9BU4	Dioxys cincta (Megachilidae)	B:thiacloprid > imidacloprid, alkoxycoumarins	Hayward et al., 2023
CYP9BU5	Heriades truncorum (Megachilidae)	B: thiacloprid > imidaclprid, alkoxycoumarins	Hayward et al., 2023
CYP9DM1, DM2	Megachile rotundata	B: 7-methoxycoumarin, NOT thiacloprid or imidacloprid	Hayward et al., 2023
CYP321A1	Helicoverpa zea	B:furanocoumarins, a-naphthoflavone, a-cypermethrin, aflatoxin B1, aldrin, diazinon	Sasabe et al., 2004 Rupasinghe et al., 2007 Niu et al., 2008
CYP321A8	Spodoptera exigua	B:cypermethrin, deltamethrin, chlorpyrifos	Hu et al. 2021
CYP321A8	Spodoptera frugiperda	P:chlorpyrifos, deltamethrin, chloranthraniliprole	Chen et al., 2024
CYP321A16	Spodoptera exigua	B:chlorpyrifos	Hu et al., 2020
CYP321A19	Spodoptera litura	B:indoxacarb, DCJW	Li et al., 2023
CYP321F3	Chilo suppressalis	B:chlorantraniliprole, MR, EC, EFC, BFC	Xu et al., 2024
CYP324A12	Chilo suppressalis	B:chlorantraniliprole, MR, EC, EFC, BFC	Xu et al., 2024
CYP332A1	Spodoptera exigua	B:chlorpyrifos	Hu et al., 2020
CYP332A3	Zygaena filipendula	Val/Ile aldoximes to acetone and 2-butanone cyanohydrins	Jensen et al., 2011
CYP336A1	Apis mellifera	B: nicotine, alkaloids	Haas et al., 2023
CYP336	four Hymenoptera	B: nicotine, alkaloids	Haas et al., 2023
CYP337B3	Helicoverpa armigera	O:(H.armigera cell line)fenvalerate, cypermethrin, model substrates	Joussen et al., 2012 Rasool et al., 2014
CYP337B3v2	Helicoverpa armigera	B:esfenvalerate, EC, aldrin	Shi et al. 2021
CYP337B5	Spodoptera frugiperda	P: chlorantraniliprole	Guo et al., 2024
CYP345E2	Dendroctonus ponderosae	B: monoterpenes	Keeling et al., 2014
CYP347W1	Phaedon cochleariae	B: alanine-CoA to » isoxazoline & nitropropionic acid	Fu et al., 2021
CYP402C1	Bemisia tabaci	B:imidacloprid	Guo et al., 2022
CYP3107A10 (wrongly called CYP3A24)	Neoseiulus barkeri	B: chlorpyrifos	Yu et al., 2024
CYP4 clan
CYP4C7	Diploptera punctata	P: sesquiterpenoids	Sutherland et al., 1998
CYP4C61	Nilaparvata lugens	B: tricin, hesperetin, proquamezine, NOT imidacloprid, nitenpyram, etofenprox	Zhang et al., 2024
CYP4C62	Nilaparvata lugens	E: chlorpyrifos	Zhang et al 2023
CYP4C71	Laodelphax striatellus	B: imidacloprid, p-nitroanisole	Xiao et al. 2020
CYP4C78	Nilaparvata lugens	B: tricin, hesperetin, proquamezine, NOT imidacloprid, nitenpyram, etofenprox	Zhang et al., 2024
CYP4G2	Musca domestica	B:octadecanal	Qiu et al. 2013
CYP4G11	Apis mellifera	B:octadecanal, tetradecanal	Calla et al. 2018
CYP6G16	Anopheles gambiae	B:octadecanal	Blabanidou et al.,2016
CYP4G55	Dendroctonus ponderosae	B:octadecanol, octadecanal,7-decenal	McLean et al. 2018
CYP4G56	Dendroctonus ponderosae	B:octadecanol, decanol, octadecanal,7-decenal	McLean et al. 2018
CYP4P6	Bactrocera oleae	E: deltamethrin	Kampouraki et al., 2023
CYP4S24	Musca domestica	B: permethrin, ethoxycoumarin	Li et al., 2023
CYP4CE1	Nilaparvata lugens	E: imidacloprid	Zhang et al., 2016
CYP4CE1	Nilaparvata lugens	B: nitenpyram, imidacloprid	Zhang et al., 2024
CYP4CE1	Nilaparvata lugens	B: nitenpyram, imidacloprid NOT tricin, hesperetin, proquamezine, etofenprox	Zhang et al., 2024
CYP4FB1	Laodelphax striatellus	B: p-nitroanisole, 7-ethoxycoumarin	Yu et al. 2023
CYP325A ?	Anopheles funestus	E: pyrethroids	Wamba et al., 2021
CYP340G2	Spodoptera litura	B:indoxacarb, DCJW	Li et al., 2023
CYP340BD2	Ascotis selenaria	B: epoxide sex pheromone biosynthesis	Rong et al. 2019a
CYP341B14	Hyphantria cunea	B: epoxide sex pheromone biosynthesis	Rong et al.2014
CYP341B14	Lemyra imparilis	B: epoxide sex pheromone biosynthesis	Rong et al. 2019b
CYP389C16	Tetranychus cinnabarinus	E: cyflumetofen, pyridaben, AB-1	Feng et al., 2020
CYP405A2	Zygaena filipendula	Y:Val/Ile to their aldoximes	Jensen et al., 2011
CYP417A2v2	Laodelphax striatellus	B:imidacloprid,p-nitroanisole, 7EC	Miah et al. 2017
CYP439A1v3	Laodelphax striatellus	B: deltamethrin, p-nitroanisole, EC, ER, reports negatives	Miah et al. 2019
CYP439A2	Nilaparvata lugens	B: etofenprox NOT nitenpyram, imidacloprid,tricin, hesperetin, proquamezine	Zhang et al., 2024
Mito clan
CYP12A1	Musca domestica	P: aldrin, heptachlor, diazinon, azinphosmethyl, amitraz,progesterone, testosterone, 7-alkoxycoumarins	Guzov et al. 1998
CYP301B1	Helicoverpa armigera	B: BOMR	Shi et al. 2022
CYP301B1	Laodelphax striatellus	B: p-nitroanisole, 7-ethoxycoumarin	Yu et al. 2023
CYP302A1	Drosophila melanogaster	D:2,22-dideoxyecdysone	Warren et al. 2002
CYP302A1	Bombyx mori	D:2,22-dideoxyecdysone	Niwa et al. 2005
CYP302A1	Anopheles gambiae	D:2,22-dideoxyecdysone	Pondeville et al. 2008
CYP302A1	Mamestra brassicae	D: 2,22-dideoxyecdysone	Ogihara et al. 2017
CYP302A1	Helicoverpa armigera	B: BOMR	Shi et al. 2022
CYP302A1	Nilaparvata lugens	D: ketotriol- NO MET to 2dE	Zhou et al. 2020
CYP314A1	Drosophila melanogaster	D: ecdysone	Petryk et al 2003
CYP314A1	Bombyx mori	B: ecdysone	Meada et al. 2008
CYP314A1	Anopheles gambiae	D: ecdysone	Pondeville et al. 2008
CYP314A1	Leptinotarsa decemlineata	B: ecdysone	Kong et al., 2014
CYP314A1	Mamestra brassicae	D: ecdysone	Ogihara et al. 2017
CYP314A1	Nilaparvata lugens	D: ecdysone	Zhou et al. 2020
CYP315A1	Drosophila melanogaster	D:2-deoxyecdysone,2,22-dideoxyecdysone	Warren et al. 2002
CYP315A1	Anopheles gambiae	D:2-deoxyecdysone, 2,22-dideoxyecdysone	Pondeville et al. 2008
CYP315A1	Mamestra brassicae	D: 2-deoxyecdysone	Ogihara et al. 2017
CYP315A1	Helicoverpa armigera	B: ethoxycoumarin	Shi et al. 2022
CYP315A1	Nilaparvata lugens	D: 2-deoxyecdysone	Zhou et al. 2020
CYP315A1	Apis mellifera	E: NOT imidacloprid or thiacloprid	Alptekin et al., 2016
CYP333B3	Helicoverpa armigera	B: ethoxycoumarin, aldrin	Shi et al. 2022
CYP339A1	Helicoverpa armigera	B: esfenvalerate	Shi et al. 2022
CYP339A1	Spodoptera litura	B:indoxacarb, DCJW	Li et al., 2023
CYP353D1v2	Laodelphax striatellus	B: buprofezin, imidacloprid, p-nitroanisole	Elzaki et al., 2017a,b