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Zeng, X., Pan, Y., Tian, F., Li, J., Xu, H., Liu, X., Chen, X., Gao, X., Peng, T., Bi, R., Shang, Q., 2021. Functional validation of key cytochrome P450 monooxygenase and UDP-glycosyltransferase genes conferring cyantraniliprole resistance in Aphis gossypii Glover. Pesticide Biochemistry and Physiology 176, 104879. https://doi.org/10.1016/j.pestbp.2021.104879

Zhang, B., Zhang, L., Cui, R., Zeng, X., Gao, X., 2016. Cloning and Expression of Multiple Cytochrome P450 Genes: Induction by Fipronil in Workers of the Red Imported Fire Ant (Solenopsis invicta Buren). PLoS ONE 11, e0150915. https://doi.org/10.1371/journal.pone.0150915

Zhang, B.-Z., Jiang, Y.-T., Cui, L.-L., Hu, G.-L., Li, X.-A., Zhang, P., Ji, X., Ma, P.-C., Kong, F.-B., Liu, R.-Q., 2024. microRNA-3037 targeting CYP6CY2 confers imidacloprid resistance to Sitobion miscanthi (Takahashi). Pesticide Biochemistry and Physiology 202, 105958. https://doi.org/10.1016/j.pestbp.2024.105958

Zhang, B.-Z., Su, X., Xie, L.-F., Zhen, C.-A., Hu, G.-L., Jiang, K., Huang, Z.Y., Liu, R.-Q., Gao, Y.-F., Chen, X.-L., Gao, X.-W., 2020. Multiple detoxification genes confer imidacloprid resistance to Sitobion avenae Fabricius. Crop Protection 128, 105014. https://doi.org/10.1016/j.cropro.2019.105014

Zhang BZ, Hu GL, Lu LY, Chen XL, Gao XW. 2022. Silencing of CYP6AS160 in Solenopsis invicta Buren by RNA interference enhances worker susceptibility to fipronil. Bull Entomol Res.112, 171-178. https://doi.org/10.1017/S0007485321000651.

Zhang C, Du S, Liu R, Dai W. 2022. Overexpression of Multiple Cytochrome P450 Genes Conferring Clothianidin Resistance in Bradysia odoriphaga. J Agric Food Chem. 70,7636-7643. https://doi.org/10.1021/acs.jafc.2c01315.

Zhang C, Li Y, Qiu T, Wang Y, Wang H, Wang K, Dai W. 2024. Functional Characterization of CYP6QE1 and CYP6FV21 in Resistance to λ-Cyhalothrin and Imidacloprid in Bradysia odoriphaga. J Agric Food Chem.72:2925-2934. https://doi.org/10.1021/acs.jafc.3c08807

Zhang, C., Luo, X., Ni, X., Zhang, Y., Li, X., 2010. Functional characterization of cis-acting elements mediating flavone-inducible expression of CYP321A1. Insect Biochemistry and Molecular Biology 40, 898–908. https://doi.org/10.1016/j.ibmb.2010.09.003

Zhang, C., Wan, B., Jin, M.-R., Wang, J., Xin, T.-R., Zou, Z.-W., Xia, B., 2023. The loss of Halloween gene function seriously affects the development and reproduction of Diaphorina citri (Hemiptera: Liviidae) and increases its susceptibility to pesticides. Pesticide Biochemistry and Physiology 191, 105361. https://doi.org/10.1016/j.pestbp.2023.105361

Zhang, C., Wang, X., Tai, S., Qi, L., Yu, X., Dai, W., 2023. Transcription factor CncC potentially regulates cytochrome P450 CYP321A1-mediated flavone tolerance in Helicoverpa armigera. Pesticide Biochemistry and Physiology 191, 105360. https://doi.org/10.1016/j.pestbp.2023.105360

Zhang, C., Wong, A., Zhang, Y., Ni, X., Li, X., 2014. Common and unique cis-acting elements mediate xanthotoxin and flavone induction of the generalist P450 CYP321A1. Sci Rep 4, 6490. https://doi.org/10.1038/srep06490

Zhang H, Lin X, Yang B, Zhang L, Liu Z. 2024. Two Point Mutations in CYP4CE1 Promoter Contributed to the Differential Regulation of CYP4CE1 Expression by FoxO between Susceptible and Nitenpyram-Resistant Nilaparvata lugens. J Agric Food Chem. 72,1779-1786. https://doi.org/10.1021/acs.jafc.3c02495

Zhang, H., Tang, T., Cheng, Y., Shui, R., Zhang, W., Qiu, L., 2010. Cloning and expression of cytochrome P450 CYP6B7 in fenvalerate-resistant and susceptible Helicoverpa armigera (Hübner) from China. Journal of Applied Entomology 134, 754-761.

Zhang, H., Yang, H., Dong, W., Gu, Z., Wang, C., Chen, A., Shi, X., Gao, X., 2022. Mutations in the nAChR β1 subunit and overexpression of P450 genes are associated with high resistance to thiamethoxam in melon aphid, Aphis gossypii Glover. Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology 258, 110682. https://doi.org/10.1016/j.cbpb.2021.110682

Zhang, H., Gao, H., Lin, X., Yang, B., Wang, J., Yuan, X., Zhang, Z., He, T., Liu, Z., 2024. Akt-FoxO signaling drives co-adaptation to insecticide and host plant stresses in an herbivorous insect. Journal of Advanced Research S2090123224004983. https://doi.org/10.1016/j.jare.2024.11.006

Zhang, J., Zhang, Y., Wang, Y., Yang, Y., Cang, X., Liu, Z., 2016. Expression induction of P450 genes by imidacloprid in Nilaparvata lugens: A genome-scale analysis. Pesticide Biochemistry and Physiology 132, 59–64. https://doi.org/10.1016/j.pestbp.2015.10.016

Zhang, J.-H., Zhao, M., Zhou, Y.-J., Xu, Q.-F., Yang, Y.-X., 2021. Cytochrome P450 Monooxygenases CYP6AY3 and CYP6CW1 Regulate Rice Black-Streaked Dwarf Virus Replication in Laodelphax striatellus (Fallén). Viruses 13, 1576. https://doi.org/10.3390/v13081576

Zhang, H., Zhang, Z., Zhang, Y., Zhang, X., Liu, Z., 2024. CYP4CE1 Metabolized Nitenpyram through Two Types of Oxidation Reaction, Hydroxylation, and N-Demethylation. J. Agric. Food Chem. 72, 20122–20129. https://doi.org/10.1021/acs.jafc.4c06273

Zhang, H., Zou, J., Yang, B., Zhang, Y., Liu, Z., 2023. Importance of CYP6ER1 Was Different among Neonicotinoids in Their Susceptibility in Nilaparvata lugens. J. Agric. Food Chem. 71, 4163–4171. https://doi.org/10.1021/acs.jafc.2c07692

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Zhang, L., Lu, Y., Xiang, M., Shang, Q., Gao, X., 2016. The retardant effect of 2-Tridecanone, mediated by Cytochrome P450, on the Development of Cotton bollworm, Helicoverpa armigera. BMC Genomics 17, 954. https://doi.org/10.1186/s12864-016-3277-y

Zhang, L., Lv, S., Li, M., Gu, M., Gao, X., 2022. A General Signal Pathway to Regulate Multiple Detoxification Genes Drives the Evolution of Helicoverpa armigera Adaptation to Xenobiotics. IJMS 23, 16126. https://doi.org/10.3390/ijms232416126

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Zhang, M., Scott, J.G., 1996. Cytochrome b5 is Essential for Cytochrome P450 6D1-Mediated Cypermethrin Resistance in LPR House Flies. Pesticide Biochemistry and Physiology 55, 150–156. https://doi.org/10.1006/pest.1996.0044

Zhang, M, Scott, J. G. 1996. Purification and characterization of cytochrome b5 reductase from the house fly, Musca domestica. Comp. Biochem. Physiol. 113B, 175-83.

Zhang, M.-Y., Zhang, P., Su, X., Guo, T.-X., Zhou, J.-L., Zhang, B.-Z., Wang, H.-L., 2022. MicroRNA-190-5p confers chlorantraniliprole resistance by regulating CYP6K2 in Spodoptera frugiperda (Smith). Pesticide Biochemistry and Physiology 184, 105133. https://doi.org/10.1016/j.pestbp.2022.105133 [this is not CYP6K2 but CYP324A18]

Zhang, Q., Tang, J., Gao, B., Qu, C., Wang, J., Luo, C., Wang, R., 2024. Overexpression of CYP6CX4 contributing to field-evolved resistance to flupyradifurone, one novel butenolide insecticide, in Bemisia tabaci from China. International Journal of Biological Macromolecules 265, 131056. https://doi.org/10.1016/j.ijbiomac.2024.131056

Zhang, T., Gong, C., Pu, J., Peng, A., Li, X., Wang, Y., Wang, X., 2023. Enhancement of tolerance against flonicamid in Solenopsis invicta (Hymenoptera: Formicidae) through overexpression of CYP6A14. Pesticide Biochemistry and Physiology 197, 105651. https://doi.org/10.1016/j.pestbp.2023.105651 [ this is not CYP6A14 but CYP6AS161]

Zhang, T., Gong, C., Pu, J., Peng, A., Yang, J., Wang, X., 2025. Enhancement of Tolerance against Flonicamid in Solenopsis invicta Queens through Overexpression of CYP6AQ83. J. Agric. Food Chem. 73, 237–248. https://doi.org/10.1021/acs.jafc.4c08903

Zhang, R., Kang, K.-D., Shan, G., Hammock, B., 2003. Design, synthesis and evaluation of novel P450 fluorescent probes bearing [alpha]-cyanoether. Tetrahedron Letters 44, 4331-4334.

Zhang, W., Yao, Y., Wang, H., Liu, Z., Ma, L., Wang, Y., Xu, B., 2019. The Roles of Four Novel P450 Genes in Pesticides Resistance in Apis cerana cerana Fabricius: Expression Levels and Detoxification Efficiency. Front. Genet. 10, 1000. https://doi.org/10.3389/fgene.2019.01000

Zhang, X., Dong, J., Wu, H., Zhang, H., Zhang, J., Ma, E., 2019. Knockdown of cytochrome P450 CYP6 family genes increases susceptibility to carbamates and pyrethroids in the migratory locust, Locusta migratoria. Chemosphere 223, 48–57. https://doi.org/10.1016/j.chemosphere.2019.02.011

Zhang, X., He, Q., Zhang, T., Wu, H., Zhang, J., Ma, E., 2021. Characteristics of Halloween genes and RNA interference‐mediated functional analysis of LmCYP307a2 in Locusta migratoria. Insect Science 29, 51–64. https://doi.org/10.1111/1744-7917.12907

Zhang, X., Kang, X., Wu, H., Silver, K., Zhang, J., Ma, E., Zhu, K.Y., 2018. Transcriptome-wide survey, gene expression profiling and exogenous chemical-induced transcriptional responses of cytochrome P450 superfamily genes in migratory locust (Locusta migratoria). Insect Biochemistry and Molecular Biology 100, 66–77. https://doi.org/10.1016/j.ibmb.2018.06.006

Zhang, X., Liu, M., Cheng, A., Moussian, B., Zhang, J., Dong, W., 2024. Role of CYP311A1 in wing development of Drosophila melanogaster. Insect Science 1744-7917.13342. https://doi.org/10.1111/1744-7917.13342

Zhang, X., Liu, X., Ma, J., Zhao, J., 2013. Silencing of cytochrome P450 CYP6B6 gene of cotton bollworm ( Helicoverpa armigera ) by RNAi. Bull. Entomol. Res. 103, 584–591. https://doi.org/10.1017/S0007485313000151

Zhang, X., Shi, Z., Yang, C., Li, J., Liu, J., Zhang, A., 2022. Gut transcriptome analysis of P450 genes and cytochrome P450 reductase in three moth species feeding on gymnosperms or angiosperms. Front. Ecol. Evol. 10, 948043. https://doi.org/10.3389/fevo.2022.948043

Zhang, X., Wang, J., Liu, J., Li, Y., Liu, X., Wu, H., Ma, E., Zhang, J., 2017. Knockdown of NADPH-cytochrome P450 reductase increases the susceptibility to carbaryl in the migratory locust, Locusta migratoria. Chemosphere 188, 517–524. https://doi.org/10.1016/j.chemosphere.2017.08.157

Zhang, Y., Feng, Z.-J., Chen, Z.-S., Wang, X.-X., Cong, H.-S., Fan, Y.-L., Liu, T.-X., 2021. Connection between cuticular hydrocarbons and melanization in Harmonia axyridis revealed by RNAi-mediated silencing of the CYP4G79. entomologia 41, 83–96. https://doi.org/10.1127/entomologia/2020/0970

Zhang, Y., Gao, S., Xue, S., An, S., Zhang, K., 2021. Disruption of the cytochrome P450 CYP6BQ7 gene reduces tolerance to plant toxicants in the red flour beetle, Tribolium castaneum. International Journal of Biological Macromolecules 172, 263–269. https://doi.org/10.1016/j.ijbiomac.2021.01.054

Zhang, Y., Guo, H., Yang, Q., Li, S., Wang, L., Zhang, G., Fang, J., 2012. Overexpression of a P450 gene (CYP6CW1) in buprofezin-resistant Laodelphax striatellus (Fallén). Pesticide Biochemistry and Physiology 104, 277–282. https://doi.org/10.1016/j.pestbp.2012.10.002

Zhang, Y., Ju, F., 2023. Uninheritable but widespread bacterial symbiont mediates insecticide detoxification of an agricultural invasive pest Spodoptera frugiperda (preprint). Microbiology. https://doi.org/10.1101/2023.09.26.559648

Zhang, Y., Li, H., Yuan, S., Wu, H., Liu, X., Zhang, J., 2023. NADPH–cytochrome P450 reductase knockdown decreases the response to precocene I in the migratory locust Locusta migratoria. Pesticide Biochemistry and Physiology 105337. https://doi.org/10.1016/j.pestbp.2023.105337

Zhang, Y., Pan, X., Shi, T., Gu, Z., Yang, Z., Liu, M., Xu, Y., Yang, Y., Ren, L., Song, X., Lin, H., Deng, K., 2023. P450Rdb: A manually curated database of reactions catalyzed by cytochrome P450 enzymes. Journal of Advanced Research S2090123223003168. https://doi.org/10.1016/j.jare.2023.10.012

Zhang, Y.-C., Gao, Y., Ye, W.-N., Peng, Y.-X., Zhu, K.Y. and Gao, C.-F. 2023. CRISPR/Cas9-mediated knockout of NlCYP6CS1 gene reveals its role in detoxification of insecticides in Nilaparvata lugens (Hemiptera: Delphacidae). Pest Manag Sci, 79: 2239-2246. https://doi.org/10.1002/ps.7404

Zhang YX, Tan Q, Jin L, Li GQ. 2024. Molecular characterization of the cytochrome P450 enzyme CYP18A1 in Henosepilachna vigintioctopunctata. Arch Insect Biochem Physiol. 115:e22111. https://doi.org/10.1002/arch.22111.

Zhang, Y., Wang, Y., Ma, Z., Zhai, D., Gao, X., Shi, X., 2019. Cytochrome P450 monooxygenases-mediated sex-differential spinosad resistance in house flies Musca domestica (Diptera: Muscidae). Pesticide Biochemistry and Physiology 157, 178–185. https://doi.org/10.1016/j.pestbp.2019.03.024

Zhu, Y.C. and Snodgrass, G.L. 2003. Cytochrome P450 CYP6X1 cDNAs and mRNA expression levels in three strains of the tarnished plant bug Lygus lineolaris (Heteroptera: Miridae) having different susceptibilities to pyrethroid insecticide. Insect Mol. Biol., 12, 39-49.

Zhang, Yueliang, Wang, Y., Wang, L., Yao, J., Guo, H., Fang, J., 2016. Knockdown of NADPH-cytochrome P450 reductase results in reduced resistance to buprofezin in the small brown planthopper, Laodelphax striatellus (fallén). Pesticide Biochemistry and Physiology 127, 21–27. https://doi.org/10.1016/j.pestbp.2015.08.006

Zhang, Yixi, Yang, B., Yang, Z., Kai, L., Liu, Z., 2023. Alternative Splicing and Expression Reduction of P450 Genes Mediating the Oxidation of Chlorpyrifos Revealed a Novel Resistance Mechanism in Nilaparvata lugens. J. Agric. Food Chem. 71, 4036–4042. https://doi.org/10.1021/acs.jafc.2c08957

Zhang, Yixi, Yang, Y., Sun, H., Liu, Z., 2016. Metabolic imidacloprid resistance in the brown planthopper, Nilaparvata lugens, relies on multiple P450 enzymes. Insect Biochemistry and Molecular Biology 79, 50–56. https://doi.org/10.1016/j.ibmb.2016.10.009

Zhang, Z., Pei, P., Zhang, M., Li, F., Tang, G., 2023. Chromosome‐level genome assembly of Dastarcus helophoroides provides insights into CYP450 genes expression upon insecticide exposure. Pest Management Science 79, 1467–1482. https://doi.org/10.1002/ps.7319 [CYP4174B1 is wrongly called CYP6A14X1; CYP4Q85 is wrongly called CYP4Q; CYP4ABT1 is wrongly called CYP4C1]

Zhang, Z., Wang, D., Shan, Y., Chen, J., Hu, H., Song, X. et al. 2023. Knockdown of CYP9A9 increases the susceptibility to lufenuron, methoxyfenozide and a mixture of both in Spodoptera exigua. Insect Molecular Biology, 32, 263–276. https://doi.org/10.1111/imb.12829

Zhang, Z., Wen, Z., Li, K., Xu, W., Liang, N., Yu, X., Li, C., Chu, D., Guo, L., 2022. Cytochrome P450 Gene, CYP6CX3, Is Involved in the Resistance to Cyantraniliprole in Bemisia tabaci. J. Agric. Food Chem. https://doi.org/10.1021/acs.jafc.2c04699

Zhao, C., Feng, X., Tang, T., Qiu, L., 2015. Isolation and Expression Analysis of CYP9A11 and Cytochrome P450 Reductase Gene in the Beet Armyworm (Lepidoptera: Noctuidae). J Insect Sci 15, 122. https://doi.org/10.1093/jisesa/iev100

Zhao, C., Song, G., Duan, H., Tang, T., Wang, C., Qiu, L., 2017. Heterologous expression of Helicoverpa armigera cytochrome P450 CYP6B7 in Pichia pastoris and interactions of CYP6B7 with insecticides Pest. Manag. Sci 73, 1866–1872. https://doi.org/10.1002/ps.4552

Zhao, C., Song, G., Silver, K., Tang, T., Wang, C., Qiu, L., 2018. Heterologous Co-expression of CYP6B7 and NADPH-Dependent Cytochrome P450 Reductase From Helicoverpa armigera (Lepidoptera: Noctuidae) in Pichia pastoris. Journal of Economic Entomology 111, 1868–1874. https://doi.org/10.1093/jee/toy116

Zhao, C., Tang, T., Feng, X., Qiu, L., 2014. Cloning and characterisation of NADPH-dependent cytochrome P450 reductase gene in the cotton bollworm, Helicoverpa armigera: Cloning and characterisation of CPR gene in H. armigera. Pest. Manag. Sci. 70, 130–139. https://doi.org/10.1002/ps.3538

Zhao, C., Tang, T., Liu, J., Feng, X., Qiu, L., 2012. Identification and expression analysis of NADH-cytochrome b5 reductase gene in the cotton bollworm, Helicoverpa armigera. Gene 511, 96–102. https://doi.org/10.1016/j.gene.2012.09.007

Zhao, G., Zhao, S., Gao, R., Wang, R., Zhang, T., Ding, H., Li, B., Lu, C., Shen, W., Wei, Z., 2011. Transcription profiling of eight cytochrome P450s potentially involved in xenobiotic metabolism in the silkworm, Bombyx mori. Pesticide Biochemistry and Physiology 100, 251–255. https://doi.org/10.1016/j.pestbp.2011.04.009

Zhao, J., Liu, X.N., Li, F., Zhuang, S.Z., Huang, L.N., Ma, J., Gao, X.W., 2016. Yeast one-hybrid screening the potential regulator of CYP6B6 overexpression of Helicoverpa armigera under 2-tridecanone stress. Bull. Entomol. Res. 106, 182–190. https://doi.org/10.1017/S0007485315000942

Zhao, J., Wei, Q., Gu, X., Ren, S., Liu, X., 2020. Alcohol dehydrogenase 5 of Helicoverpa armigera interacts with the CYP6B6 promoter in response to 2‐tridecanone. Insect Science 27, 1053–1066. https://doi.org/10.1111/1744-7917.12720

Zhao, L., Wang, C., Gao, X., Luo, J., Zhu, X., Wan, S., 2022. Characterization of P450 monooxygenase gene family in the cotton aphid, Aphis gossypii Glover. Journal of Asia-Pacific Entomology 25, 101861. https://doi.org/10.1016/j.aspen.2021.101861

Zhao, M., Zhang, F., Wang, W., Liu, Z., Ma, C., Fu, Y., Chen, W., Ma, L., 2022. Identification and Evolution Analysis of the Complete Methyl Farnesoate Biosynthesis and Related Pathway Genes in the Mud Crab, Scylla paramamosain. IJMS 23, 9451. https://doi.org/10.3390/ijms23169451

Zhao, N., He, W., Hu, H., Lv, X., Yu, F., Ji, R., Ye, X., 2024. Effect of RNAi mediated silencing of DIB , JHE , and CAM on the diapause termination of Calliptamus italicus (Orthoptera: Acrididae) eggs. Pest Management Science 80, 5780–5790. https://doi.org/10.1002/ps.8308

Zhao, P., Xue, H., Zhu, X., Wang, L., Zhang, K., Li, D., Ji, J., Niu, L., Gao, X., Luo, J., Cui, J., 2022a. Silencing of cytochrome P450 gene CYP321A1 effects tannin detoxification and metabolism in Spodoptera litura. International Journal of Biological Macromolecules 194, 895–902. https://doi.org/10.1016/j.ijbiomac.2021.11.144

Zhao, P., Xue, H., Zhu, X., Wang, L., Zhang, K., Li, D., Ji, J., Niu, L., Gao, X., Luo, J., Cui, J., 2022b. Knockdown of cytochrome P450 gene CYP6AB12 based on nanomaterial technology reduces the detoxification ability of Spodoptera litura to gossypol. Pesticide Biochemistry and Physiology 188, 105284. https://doi.org/10.1016/j.pestbp.2022.105284

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