Transgenic expression

in Drosophila unless indicated otherwise O: (other). Transgenic overexpression in the same organism is indicated as (OE). Result is lower toxicity or metabolism of the listed chemical(s) unless indicated otherwise (i.e. bioactivation leading to higher toxicity).

CYP	species	transgenic expression	reference
CYP2 clan
CYP15C1	Bombyx mori	O:(Bombyx) rescues mod mutation	Daimon et al., 2012
CYP303A1	Drosophila melanogaster	rescues null mutations	Wu et al., 2019
CYP304A1	Aedes albopictus	haedoxan A	Pei et al., 2022
CYP392A11	Tetranychus urticae	fenproximate	Riga et al., 2015
CYP392A16	Tetranychus urticae	abamectin	Riga et al., 2014; 2020
CYP392D8	Tetranychus urticae	no effect on abamectin toxicity	Xu et al., 2023
CYP3 clan
CYP6A36	Musca domestica	permethrin	Li et al. 2023
CYP6A51	Ceratitis capitata	λ-cyhalothrin, deltamethrin	Tsakireli et al. 2019
CYP6D1	Musca domestica	benzo[a]pyrene	Korytko et al., 2000
CYP6D10	Musca domestica	permethrin	Li et al., 2023
CYP6G1	Drosophila melanogaster	(OE)DDT	Daborn et al. 2002, Daborn et al., 2007
CYP6G1	Drosophila melanogaster	(OE)DDT, dicyclanil, nitenpyram	Daborn et al., 2007, Chung et al. 2007
CYP6G1	Drosophila melanogaster	(OE)azinphos-methyl	Battlay et al. 2016
CYP6G1	Drosophila melanogaster	(OE)imidacloprid	Denecke et al. 2017
CYP6G1	Drosophila melanogaster	(OE)bendiocarb, imidacloprid, malathion	Luong et al., 2022
CYP6G2	Drosophila melanogaster	(OE)nitenpyram, diazinon	Daborn et al. 2007
CYP6G2	Drosophila melanogaster	(OE)imidacloprid	Denecke et al. 2017
CYP6G4	Musca domestica	propoxur	Zhu et al., 2022
CYP6G4 wt & mut	Musca domestica	propoxur	You et al., 2023
CYP6G4	Musca domestica	chlorpyrifos, tetramethrin, methomyl, acetamiprid, imidacloprid, NOT permethrin	Zhu et al., 2023
CYP6M2	Anopheles gambiae	pyrethroids, DDT, bendiocarb	Stevenson et al., 2011 Mitchell et al., 2012 Edi et al., 2014
CYP6M2	Anopheles gambiae	O:(A.gambiae) pyrethroids, malathion(activation)	Adolfi et al. 2019
CYP6M7	Anopheles funestus	pyrethroids	Riveron et al.,2014
CYP6P3	Anopheles gambiae	pyrethroids, bendiocarb	Muller et al., 2008 Edi et al., 2014
CYP6P3	Anopheles gambiae	O:(A.gambiae) pyrethroids	Adolfi et al. 2019
CYP6P3 (E205D allele)	Anopheles gambiae	pyrethroids, propoxur,bendiocarb, NOT DDT	Kengne-Ouafo et al., 2024
CYP6P4a Mwi	Anopheles funestus	permethrin, deltamethrin	Tatchou-Nebangwa et al., 2024
CYP6P4a Ghana	Anopheles funestus	permethrin, deltamethrin, a-cypermethrin	Tatchou-Nebangwa et al., 2024
CYP6P4b Ghana	Anopheles funestus	permethrin,deltamethrin,a-cypermethrin	Tatchou-Nebangwa et al., 2024
CYP6P4b Moz	Anopheles funestus	permethrin,deltamethrin, a-cypermethrin	Tatchou-Nebangwa et al., 2024
CYP6P5	Anopheles albimanus	pyrethroids	Kusimo et al. 2022
CYP6P9a	Anopheles funestus	pyrethroids	Riveron et al., 2013 Ibrahim et al., 2015
CYP6P9a	Anopheles funestus	clothianidin, chlorfenapyr (activation)	Tchouakui et al., 2024
CYP6P9b	Anopheles funestus	pyrethroids	Riveron et al., 2013 Ibrahim et al., 2015
CYP6P9b	Anopheles funestus	clothianidin, chlorfenapyr (activation)	Tchouakui et al., 2024
CYP6P12	Aedes albopictus	permethrin	Ishak et al. 2016
CYP6W1	Drosophila melanogaster	(OE) DDT	Schmidt et al. 2017
CYP6Z2	Anopheles coluzzi	a-cypermethrin, deltamethrin, clothianidin(higher toxicity)	Ibrahim et al., 2023
CYP6AA1	Anopheles funestus	pyrethroids	Ibrahim et al., 2018
CYP6AB12	Spodoptera litura	cyantraniliprole	Li et al., 2023
CYP6AB45	Chilo suppressalis	no effect on chlorantraniliprole, abamectin, triazophos, sinetoram tox.	Wang et al., 2024
CYP6AB58	Spodoptera litura	no effect on cyantraniliprole tox.	Li et al., 2023
CYP6AB59	Spodoptera litura	cyantraniliprole	Li et al., 2023
CYP6AE44	Spodoptera litura	abamectin	Liang et al., 2024
CYP6AE70	Spodoptera exigua	chlorpyrifos, cypermethrin, deltamethrin	Hu et al., 2024
CYP6AE178	Hyphantria cunea	cytisine, coumarin	Li et al., 2024
CYP6AN4	Spodoptera litura	cyantraniliprole, by feeding, not topical	Li et al., 2023
CYP6AQ83	Solenopsis invicta	flonicamid	Zhang et al., 2024
CYP6AS161(called 6A14)	Solenopsis invicta	flonicamid	Zhang et al., 2023
CYP6AY1	Nilaparvata lugens	imidacloprid	cited in McLeman et al., 2020
CYP6AY3v2	Laodelphax striatellus	imidacloprid	Wang et al. 2017
CYP6BG1	Plutella xylostella	chlorantraniliprole, cypermethrin, NOT abamectin	Li et al., 2017
CYP6BG1	Plutella xylostella	chlorantraniliprole	Mallott et al., 2019
CYP6BQ9	Tribolium castaneum	deltamethrin	Zhu et al., 2010
CYP6BQ9	Tribolium castaneum	O:(Fall armyworm) deltamethrin	Chen and Palli 2021
CYP6BQ23	Meligethes (Brassicogethes) aeneus	deltamethrin	Samantsidis et al., 2020
CYP6CM1vQ	Bemisia tabaci	imidacloprid, nitenpyram	Daborn et al., 2012
CYP6CM1(A387G)	Bemisia tabaci	imidacloprid, clothianidin	Pym et al., 2023a
CYP6CS1	Nilaparvata lugens	pymetrozine	Wang et al., 2021
CYP6CX3	Bemisia tabaci	cyantraniliprole	Zhang et al., 2022
CYP6CX4	Bemisia tabaci	flupyradifurone	Zhang et al., 2024
CYP6CY3	Myzus persicae nicotianae	nicotine, clothianidin	Bass et al., 2013
CYP6CY3	Myzus persicae nicotianae	nicotine	McLeman et al., 2020
CYP6CY4	Myzus persicae nicotianae	nicotine	McLeman et al., 2020
CYP6CY5	Aphis gossypii	cyantraniliprole	Ding et al. 2023
CYP6CY7	Aphis gossypii	cyantraniliprole, a-cypermethrin	Zeng et al. 2021
CYP6CY9	Aphis gossypii	thiamethoxam, imidacloprid	Lv et al. 2022
CYP6CY9	Aphis gossypii	cyantraniliprole	Ding et al. 2023
CYP6CY18	Aphis gossypii	imidacloprid	Lv et al. 2022
CYP6CY19	Aphis gossypii	cyantraniliprole	Ding et al. 2023
CYP6CY21	Aphis gossypii	cyantraniliprole, a-cypermethrin	Zeng et al. 2021
CYP6CY22	Aphis gossypii	imidacloprid	Lv et al. 2022
CYP6CY22	Aphis gossypii	cyantraniliprole, xanthotoxin, quercetin, 2-tridecanone,tannic acid, nicotine	Ding et al. 2024
CYP6CZ1	Aphis gossypii	thiamethoxam	Lv et al. 2022
CYP6CZ1	Aphis gossypii	cyantraniliprole	Ding et al. 2023
CYP6DA1	Aphis gossypii	cyantraniliprole	Ding et al. 2023
CYP6DB1	Aphis gossypii	thiamethoxam	Lv et al. 2022
CYP6DB1	Aphis gossypii	cyantraniliprole	Ding et al. 2023
CYP6DB3	Bemisia tabaci	imidacloprid, thiamethoxam	Wei et al., 2023
CYP6DD1	Aphis gossypii	cyantraniliprole	Ding et al. 2023
CYP6DP1	Trialeurodes vaporarium	imidacloprid,nicotine	Pym et al., 2023b
CYP6DP2	Trialeurodes vaporarium	imidacloprid,nicotine	Pym et al., 2023b
CYP6DP3	Bemisia tabaci	imidacloprid,nicotine	Pym et al., 2023b
CYP6DP5	Bemisia tabaci	imidacloprid,NOT nicotine	Pym et al., 2023b
CYP6EM1	Bemisia tabaci	dinetofuran	Huang et al., 2024
CYP6ER1	Nilaparvata lugens	imidacloprid	Pang et al., 2016
CYP6ER1	Nilaparvata lugens	imidacloprid	Zimmer et al., 2018
CYP6ER1vA	Nilaparvata lugens	imidacloprid,nitenpyram,cycloxaprid; NOT sulfoxaflor,triflumezopyrim,pymetrozine	Gong et al., 2023
CYP6FJ3	Sogatella furcifera	pymetrozine	Gong et al., 2023
CYP6FU1	Laodelphax striatellus	NOT fenvalerate	Yu et al., 2023
CYP6FV21	Bradysia odoriphaga	imidacloprid, λ-cyhalothrin	Zhang et al., 2024
CYP6QE1	Bradysia odoriphaga	imidacloprid, λ-cyhalothrin	Zhang et al., 2024
CYP9A32	Spodoptera litura	abamectin	Liang et al., 2024
CYP9A157 (called CYP9A75a)	Spodoptera litura	cyantraniliprole, a-cypermethrin, nicotine	Li et al., 2024
CYP9A158 (called CYP9A75b)	Spodoptera litura	cyantraniliprole, a-cypermethrin, nicotine	Li et al., 2024
CYP9A186(F116V)	Spodoptera exigua	O(H.armigera) emamectin benzoate,abamectin (high R)	Li et al., 2023
CYP9A186(F116V)	Spodoptera exigua	emamectin benzoate,abamectin (low R)	Li et al., 2023
CYP9A186	Spodoptera exigua	O(Plutella xylostella) emamectin benzoate, abamectin	Wang et al., 2024
CYP9J11	Anopheles funestus	pyrethroids	Riveron et al., 2017
CYP9J28	Aedes aegypti	pyrethroids	Stevenson et al., 2012; Pavlidi et al.,2012; Samantsidis et al., 2020
CYP9K1(G454A)	Anopheles funestus	more R than wt: deltamethrin, cypermethrin, permethrin	Djoko et al.,2025
CYP9Q1	Apis mellifera	thiacloprid	Manjon et al.2018
CYP9Q2	Apis mellifera	thiacloprid	Manjon et al.2018
CYP9Q2	Apis mellifera	flupyradifurone	Haas et al. 2021
CYP9Q2	Apis mellifera	chlorantraniliprole, NOT flubendiamide	Haas et al. 2022
CYP9Q2	Apis mellifera	coumaphos, coumaphos oxon	Xiao et al. 2024
CYP9Q3	Apis mellifera	thiacloprid	Manjon et al.2018
CYP9Q3	Apis mellifera	flupyradifurone	Haas et al. 2021
CYP9Q3	Apis mellifera	chlorantraniliprole, NOT flubendiamide	Haas et al. 2022
CYP9Q3	Apis mellifera	coumaphos, coumaphos oxon	Xiao et al. 2024
CYP9Q4	Bombus terrestris	thiacloprid	Manjon et al.2018
CYP9Q5	Bombus terrestris	thiacloprid	Manjon et al.2018
CYP9Q6	Bombus terrestris	thiacloprid, acetamiprid	Troczka et al.,2019
CYP9R38	Osmia bicornis	thiacloprid	Beadle et al., 2019
CYP9BU1	Osmia bicornis	thiacloprid, NOT imidacloprid	Beadle et al., 2019
CYP9BU2	Osmia bicornis	NOT thiacloprid or imidacloprid	Beadle et al., 2019
CYP321A7	Spodoptera frugiperda	λ-cyhalothrin	Li et al.,2024
CYP321A8	Spodoptera frugiperda	O:(Fall armyworm) deltamethrin	Chen and Palli 2021
CYP321A9	Spodoptera frugiperda	gramin, tricin	He et al., 2023
CYP321A16	Spodoptera exigua	chlorpyrifos	Hu et al., 2020
CYP321A19	Spodoptera litura	indoxacarb,chlorantraniliprole,λ-cyhalothrin,imidacloprid NOT chlorpyrifos	Li et al., 2023
CYP332A1	Spodoptera exigua	chlorpyrifos	Hu et al., 2020
CYP332A1	Spodoptera litura	cyantraniliprole (by feeding, not topical)	Li et al., 2023
CYP337B3	Helicoverpa armigera	fenvalerate	cited in McLeman et al., 2020
CYP402C1	Bemisia tabaci	imidacloprid	Guo et al., 2022
CYP4 clan
CYP4D24	Aedes aegypti	permethrin	Reid et al., 2014
CYP4G15	Aphis gossypii	cyantraniliprole	Ding et al. 2023
CYP4H29	Aedes aegypti	permethrin	Reid et al., 2014
CYP4H33	Aedes aegypti	permethrin	Reid et al., 2014
CYP4J15v1	Aedes aegypti	permethrin	Reid et al., 2014
CYP4S9	Spodoptera litura	abamectin	Liang et al., 2024
CYP4S24	Musca domestica	permethrin	Li et al., 2023
CYP4CJ1	Aphis gossypii	cyantraniliprole	Zeng et al. 2021
CYP4CK1	Aphis gossypii	thiamethoxam	Lv et al. 2022
CYP4CK1	Aphis gossypii	cyantraniliprole	Ding et al. 2023
CYP4CL2	Panonychus citri	pyridaben	Pan et al., 2023
CYP4CS5	Bemisia tabaci	thiamethoxam, clothianidin	Hu et al., 2024
CYP4FB1	Laodelphax striatellus	deltamethrin, fenvalerate, etofenprox	Yu et al., 2023
CYP340G2	Spodoptera litura	indoxacarb,chlorantraniliprole,λ-cyhalothrin,imidacloprid NOT chlorpyrifos,λ-cyhalothrin	Li et al., 2023
CYP380C6	Aphis gossypii	spirotetramat	Pan et al. 2018
CYP380C6	Aphis gossypii	cyantraniliprole, a-cypermethrin	Zeng et al. 2021
CYP380C40	Myzus persicae	sulfoxaflor	Pym et al., 2022
CYP340L25 (called 340L)	Spodoptera litura	no effect on cyantraniliprole tox	Li et al., 2023
CYP340AX8 (called 340A)	Spodoptera litura	cyantraniliprole	Li et al., 2023
CYP439A1	Laodelphax striatellus	NOT fenvalerate	Yu et al., 2023
Mito clan
CYP12A4	Drosophila melanogaster	(OE) lufenuron	Bogwitz et al., 2005
CYP12A5	Drosophila melanogaster	(OE) nitenpyram (activation)	Harrop et al. 2018
CYP12D1	Drosophila melanogaster	(OE) DDT, dicyclanil	Daborn et al. 2007
CYP12D1	Drosophila melanogaster	(OE) malathion	Battlay et al. 2018
CYP301B1	Laodelphax striatellus	deltamethrin, fenvalerate, etofenprox	Yu et al., 2023
CYP339A1	Spodoptera litura	indoxacarb,chlorantraniliprole,λ-cyhalothrin,imidacloprid NOT chlorpyrifos	Li et al., 2023