transgenic_expression
Transgenic expression
in Drosophila unless indicated otherwise O: (other). Transgenic overexpression in the same organism is indicated as (OE). Result is lower toxicity or metabolism of the listed chemical(s) unless indicated otherwise (i.e. bioactivation leading to higher toxicity).
Use the filter below to search by CYP, species, pesticide, etc.
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| CYP | species | transgenic expression | reference | |
|---|---|---|---|---|
| CYP2 clan | ||||
| CYP15C1 | Bombyx mori | O:(Bombyx) rescues mod mutation | Daimon et al., 2012 | |
| CYP303A1 | Drosophila melanogaster | rescues null mutations | Wu et al., 2019 | |
| CYP304B1 (called CYP304A1) | Aedes albopictus | haedoxan A | Pei et al., 2022 | |
| CYP307A2 | Nilaparvata lugens | dinotefuran,imidacloprid,nitenpyram | Zhang et al., 2023 | |
| CYP392A11 | Tetranychus urticae | fenproximate | Riga et al., 2015 | |
| CYP392A16 | Tetranychus urticae | abamectin | Riga et al., 2014; 2020 | |
| CYP392D8 | Tetranychus urticae | no effect on abamectin toxicity | Xu et al., 2023 | |
| CYP3 clan | ||||
| CYP6A36 | Musca domestica | permethrin | Li et al. 2023 | |
| CYP6A51 | Ceratitis capitata | λ-cyhalothrin, deltamethrin | Tsakireli et al. 2019 | |
| CYP6B50 | Spodoptera frugiperda | chlorantraniliprole, tetrachlorantraniliprole,indoxacarb,λ-cyhalothrin, deltamethrin (also in vivo metabolism of these insecticides) | Guo et al., 2025 | |
| CYP6D1 | Musca domestica | benzo[a]pyrene | Korytko et al., 2000 | |
| CYP6D10 | Musca domestica | permethrin | Li et al., 2023 | |
| CYP6G1 | Drosophila melanogaster | (OE)DDT | Daborn et al. 2002, Daborn et al., 2007 | |
| CYP6G1 | Drosophila melanogaster | (OE)DDT, dicyclanil, nitenpyram | Daborn et al., 2007, Chung et al. 2007 | |
| CYP6G1 | Drosophila melanogaster | (OE)azinphos-methyl | Battlay et al. 2016 | |
| CYP6G1 | Drosophila melanogaster | (OE)imidacloprid | Denecke et al. 2017 | |
| CYP6G1 | Drosophila melanogaster | (OE)imidacloprid,nitenpyram | Giang et al. 2025 | |
| CYP6G1 | Drosophila melanogaster | (OE)bendiocarb, imidacloprid, malathion | Luong et al., 2022 | |
| CYP6G2 | Drosophila melanogaster | (OE)nitenpyram, diazinon | Daborn et al. 2007 | |
| CYP6G2 | Drosophila melanogaster | (OE)imidacloprid | Denecke et al. 2017 | |
| CYP6G1 | Drosophila melanogaster | (OE)imidacloprid, nitenpyram | Giang et al. 2025 | |
| CYP6G4 | Musca domestica | propoxur | Zhu et al., 2022 | |
| CYP6G4 wt & mut | Musca domestica | propoxur | You et al., 2023 | |
| CYP6G4 | Musca domestica | chlorpyrifos, tetramethrin, methomyl, acetamiprid, imidacloprid, NOT permethrin | Zhu et al., 2023 | |
| CYP6M2 | Anopheles gambiae | pyrethroids, DDT, bendiocarb | Stevenson et al., 2011 Mitchell et al., 2012 Edi et al., 2014 | |
| CYP6M2 | Anopheles gambiae | O:(A.gambiae) pyrethroids, malathion(activation) | Adolfi et al. 2019 | |
| CYP6M7 | Anopheles funestus | pyrethroids | Riveron et al.,2014 | |
| CYP6P3 | Anopheles gambiae | pyrethroids, bendiocarb | Muller et al., 2008 Edi et al., 2014 | |
| CYP6P3 | Anopheles gambiae | O:(A.gambiae) pyrethroids | Adolfi et al. 2019 | |
| CYP6P3 (E205D allele) | Anopheles gambiae | pyrethroids, propoxur,bendiocarb, NOT DDT | Kengne-Ouafo et al., 2024 | |
| CYP6P4a Mwi | Anopheles funestus | permethrin, deltamethrin | Tatchou-Nebangwa et al., 2024 | |
| CYP6P4a Ghana | Anopheles funestus | permethrin, deltamethrin, a-cypermethrin | Tatchou-Nebangwa et al., 2024 | |
| CYP6P4b Ghana | Anopheles funestus | permethrin,deltamethrin,a-cypermethrin | Tatchou-Nebangwa et al., 2024 | |
| CYP6P4b Moz | Anopheles funestus | permethrin,deltamethrin, a-cypermethrin | Tatchou-Nebangwa et al., 2024 | |
| CYP6P5 | Anopheles albimanus | pyrethroids | Kusimo et al. 2022 | |
| CYP6P9a | Anopheles funestus | pyrethroids | Riveron et al., 2013 Ibrahim et al., 2015 | |
| CYP6P9a | Anopheles funestus | clothianidin, chlorfenapyr (activation) | Tchouakui et al., 2024 | |
| CYP6P9b | Anopheles funestus | pyrethroids | Riveron et al., 2013 Ibrahim et al., 2015 | |
| CYP6P9b | Anopheles funestus | clothianidin, chlorfenapyr (activation) | Tchouakui et al., 2024 | |
| CYP6P12 | Aedes albopictus | permethrin | Ishak et al. 2016 | |
| CYP6W1 | Drosophila melanogaster | (OE) DDT | Schmidt et al. 2017 | |
| CYP6Z2 | Anopheles coluzzi | a-cypermethrin, deltamethrin, clothianidin(higher toxicity) | Ibrahim et al., 2023 | |
| CYP6AA1 | Anopheles funestus | pyrethroids | Ibrahim et al., 2018 | |
| CYP6AB12 | Spodoptera litura | cyantraniliprole | Li et al., 2023 | |
| CYP6AB14 (wrongly called CYP6AB59) | Spodoptera litura | cyantraniliprole | Li et al., 2023 | |
| CYP6AB31 (wrongly called CYP6AB58) | Spodoptera litura | no effect on cyantraniliprole tox. | Li et al., 2023 | |
| CYP6AB45 | Chilo suppressalis | no effect on chlorantraniliprole, abamectin, triazophos, sinetoram tox. | Wang et al., 2024 | |
| CYP6AB224 | Lymantria dispar | β-cypermethrin | Tan et al., 2024 | |
| CYP6AB226 | Lymantria dispar | β-cypermethrin | Tan et al., 2024 | |
| CYP6AE48 (wrongly called CYP6AE44) | Spodoptera litura | abamectin | Liang et al., 2024 | |
| CYP6AE70 | Spodoptera exigua | chlorpyrifos, cypermethrin, deltamethrin | Hu et al., 2024 | |
| CYP6AE178 | Hyphantria cunea | cytisine, coumarin | Li et al., 2024 | |
| CYP6AE184 | Hyphantria cunea | β-cypermethrin | Niu et al.,2025 | |
| CYP6AN4 | Spodoptera litura | cyantraniliprole, by feeding, not topical | Li et al., 2023 | |
| CYP6AQ83 | Solenopsis invicta | flonicamid | Zhang et al., 2024 | |
| CYP6AS161(called 6A14) | Solenopsis invicta | flonicamid | Zhang et al., 2023 | |
| CYP6AY1 | Nilaparvata lugens | NOT imidacloprid, NOT thiamethoxam, NOT buprofezin | Wu et al., 2018 | |
| CYP6AY1 | Nilaparvata lugens | imidacloprid | cited in McLeman et al., 2020 | |
| CYP6AY3v2 | Laodelphax striatellus | imidacloprid | Wang et al. 2017 | |
| CYP6BG1 | Plutella xylostella | chlorantraniliprole, cypermethrin, NOT abamectin | Li et al., 2017 | |
| CYP6BG1 | Plutella xylostella | chlorantraniliprole | Mallott et al., 2019 | |
| CYP6BQ9 | Tribolium castaneum | deltamethrin | Zhu et al., 2010 | |
| CYP6BQ9 | Tribolium castaneum | O:(Fall armyworm) deltamethrin | Chen and Palli 2021 | |
| CYP6BQ23 | Meligethes (Brassicogethes) aeneus | deltamethrin | Samantsidis et al., 2020 | |
| CYP6CM1vQ | Bemisia tabaci | imidacloprid, nitenpyram | Daborn et al., 2012 | |
| CYP6CM1(A387G) | Bemisia tabaci | imidacloprid, clothianidin | Pym et al., 2023a | |
| CYP6CS1 | Nilaparvata lugens | pymetrozine | Wang et al., 2021 | |
| CYP6CS1 | Nilaparvata lugens | dinotefuran | Zhang et al., 2023 | |
| CYP6CS1 | Nilaparvata lugens | pymetrozine, flonicamid, imidacloprid,afidopyropen, nitenpyram | Lin et al., 2025 | |
| CYP6CX3 | Bemisia tabaci | cyantraniliprole | Zhang et al., 2022 | |
| CYP6CX4 | Bemisia tabaci | flupyradifurone | Zhang et al., 2024 | |
| CYP6CY3 | Myzus persicae nicotianae | nicotine, clothianidin | Bass et al., 2013 | |
| CYP6CY3 | Myzus persicae nicotianae | nicotine | McLeman et al., 2020 | |
| CYP6CY4 | Myzus persicae nicotianae | nicotine | McLeman et al., 2020 | |
| CYP6CY5 | Aphis gossypii | cyantraniliprole | Ding et al. 2023 | |
| CYP6CY7 | Aphis gossypii | cyantraniliprole, a-cypermethrin | Zeng et al. 2021 | |
| CYP6CY9 | Aphis gossypii | thiamethoxam, imidacloprid | Lv et al. 2022 | |
| CYP6CY9 | Aphis gossypii | cyantraniliprole | Ding et al. 2023 | |
| CYP6CY14 | Aphis gossypii | cycloxaprid | Dong et al. 2025 | |
| CYP6CY18 | Aphis gossypii | imidacloprid | Lv et al. 2022 | |
| CYP6CY19 | Aphis gossypii | cyantraniliprole | Ding et al. 2023 | |
| CYP6CY21 | Aphis gossypii | cyantraniliprole, a-cypermethrin | Zeng et al. 2021 | |
| CYP6CY22 | Aphis gossypii | imidacloprid | Lv et al. 2022 | |
| CYP6CY22 | Aphis gossypii | cyantraniliprole, xanthotoxin, quercetin, 2-tridecanone,tannic acid, nicotine | Ding et al. 2024 | |
| CYP6CZ1 | Aphis gossypii | thiamethoxam | Lv et al. 2022 | |
| CYP6CZ1 | Aphis gossypii | cyantraniliprole | Ding et al. 2023 | |
| CYP6DA1 | Aphis gossypii | cyantraniliprole | Ding et al. 2023 | |
| CYP6DB1 | Aphis gossypii | thiamethoxam | Lv et al. 2022 | |
| CYP6DB1 | Aphis gossypii | cyantraniliprole | Ding et al. 2023 | |
| CYP6DB3 | Bemisia tabaci | imidacloprid, thiamethoxam | Wei et al., 2023 | |
| CYP6DD1 | Aphis gossypii | cyantraniliprole | Ding et al. 2023 | |
| CYP6DP1 | Trialeurodes vaporarium | imidacloprid,nicotine | Pym et al., 2023b | |
| CYP6DP2 | Trialeurodes vaporarium | imidacloprid,nicotine | Pym et al., 2023b | |
| CYP6DP3 | Bemisia tabaci | imidacloprid,nicotine | Pym et al., 2023b | |
| CYP6DP5 | Bemisia tabaci | imidacloprid,NOT nicotine | Pym et al., 2023b | |
| CYP6EM1 | Bemisia tabaci | dinotefuran | Huang et al., 2024 | |
| CYP6EM1 | Bemisia tabaci | thiamethoxam | Huang et al., 2025 | |
| CYP6ER1 | Nilaparvata lugens | imidacloprid | Pang et al., 2016 | |
| CYP6ER1 | Nilaparvata lugens | imidacloprid | Zimmer et al., 2018 | |
| CYP6ER1 | Nilaparvata lugens | imidacloprid, thiamethoxam, buprofezin | Wu et al., 2018 | |
| CYP6ER1 | Nilaparvata lugens | dinotefuran,imidacloprid,thiamethoxam,nitenpyram | Zhang et al., 2023 | |
| CYP6ER1vA | Nilaparvata lugens | imidacloprid,nitenpyram,cycloxaprid; NOT sulfoxaflor,triflumezopyrim,pymetrozine | Gong et al., 2023 | |
| CYP6ER1vA | Nilaparvata lugens | buprofezin | Zeng et al.2023 | |
| CYP6ER1vA | Nilaparvata lugens | ethiprole, imidacloprid, NOT fipronil | Duarte et al., 2022 | |
| CYP6ER1vA | Nilaparvata lugens | ethiprole, imidacloprid, NOT fipronil | Duarte et al., 2022 | |
| CYP6ER1vB | Nilaparvata lugens | imidacloprid,NOT ethiprole, NOT fipronil | Duarte et al., 2022 | |
| CYP6ER1vF | Nilaparvata lugens | ethiprole, imidacloprid, NOT fipronil | Duarte et al., 2022 | |
| CYP6ER1vA and vL site-directed mutants | Nilaparvata lugens | varying response to ethiprole | Duarte et al., 2022 | |
| CYP6FJ3 | Sogatella furcifera | pymetrozine | Gong et al., 2023 | |
| CYP6FU1 | Laodelphax striatellus | NOT fenvalerate | Yu et al., 2023 | |
| CYP6FV21 | Bradysia odoriphaga | imidacloprid, λ-cyhalothrin | Zhang et al., 2024 | |
| CYP6QE1 | Bradysia odoriphaga | imidacloprid, λ-cyhalothrin | Zhang et al., 2024 | |
| CYP6SN2vA | Chilo suppressalis | NOT abamectin,NOT emamectin benzoate | Wang et al., 2025 | |
| CYP6SN2vB | Chilo suppressalis | abamectin, emamectin benzoate | Wang et al., 2025 | |
| CYP9A9a (wildtype) | Spodoptera exigua | no effect on λ-cyhalothrin toxicity | Zuo et al., 2025 | |
| CYP9A9a (mutant V40L,Q160H,T208A) | Spodoptera exigua | λ-cyhalothrin | Zuo et al., 2025 | |
| CYP9A9a (mutant V40L,Q160H,T208A) | Spodoptera exigua | O(H.armigera) λ-cyhalothrin, not clorantraniliprole | Zuo et al., 2025 | |
| CYP9A40 (wrongly called CYP9A32) | Spodoptera litura | abamectin | Liang et al., 2024 | |
| CYP9A68 | Chilo suppressalis | methoxyfenozide | Guo et al., 2025 | |
| CYP9A157 (called CYP9A75a) | Spodoptera litura | cyantraniliprole, a-cypermethrin, nicotine | Li et al., 2024 | |
| CYP9A158 (called CYP9A75b) | Spodoptera litura | cyantraniliprole, a-cypermethrin, nicotine | Li et al., 2024 | |
| CYP9A186(F116V) | Spodoptera exigua | O(H.armigera) emamectin benzoate,abamectin (38.6x R) | Li et al., 2023 | |
| CYP9A186(F116V) | Spodoptera exigua | emamectin benzoate,abamectin (20x R) | Li et al., 2023 | |
| CYP9A186 | Spodoptera exigua | O(Plutella xylostella) emamectin benzoate, abamectin | Wang et al., 2024 | |
| CYP9J11 | Anopheles funestus | pyrethroids | Riveron et al., 2017 | |
| CYP9J26 | Aedes albopictus | malathion,propoxur, permethrin,deltamethrin | Zhao et al., 2025 | |
| CYP9J28 | Aedes aegypti | pyrethroids | Stevenson et al., 2012; Pavlidi et al.,2012; Samantsidis et al., 2020 | |
| CYP9K1(G454A) | Anopheles funestus | more R than wt 9K1: deltamethrin, cypermethrin, permethrin | Djoko et al.,2025 | |
| CYP9Q1 | Apis mellifera | thiacloprid | Manjon et al.2018 | |
| CYP9Q2 | Apis mellifera | thiacloprid | Manjon et al.2018 | |
| CYP9Q2 | Apis mellifera | flupyradifurone | Haas et al. 2021 | |
| CYP9Q2 | Apis mellifera | chlorantraniliprole, NOT flubendiamide | Haas et al. 2022 | |
| CYP9Q2 | Apis mellifera | coumaphos, coumaphos oxon | Xiao et al. 2024 | |
| CYP9Q3 | Apis mellifera | thiacloprid | Manjon et al.2018 | |
| CYP9Q3 | Apis mellifera | flupyradifurone | Haas et al. 2021 | |
| CYP9Q3 | Apis mellifera | chlorantraniliprole, NOT flubendiamide | Haas et al. 2022 | |
| CYP9Q3 | Apis mellifera | coumaphos, coumaphos oxon | Xiao et al. 2024 | |
| CYP9Q4 | Bombus terrestris | thiacloprid | Manjon et al.2018 | |
| CYP9Q5 | Bombus terrestris | thiacloprid | Manjon et al.2018 | |
| CYP9Q6 | Bombus terrestris | thiacloprid, acetamiprid | Troczka et al.,2019 | |
| CYP9R38 | Osmia bicornis | thiacloprid | Beadle et al., 2019 | |
| CYP9BU1 | Osmia bicornis | thiacloprid, NOT imidacloprid | Beadle et al., 2019 | |
| CYP9BU2 | Osmia bicornis | NOT thiacloprid or imidacloprid | Beadle et al., 2019 | |
| CYP321A7 | Spodoptera frugiperda | λ-cyhalothrin | Li et al.,2024 | |
| CYP321A8 | Spodoptera frugiperda | O:(Fall armyworm) deltamethrin | Chen and Palli 2021 | |
| CYP321A9 | Spodoptera frugiperda | gramin, tricin | He et al., 2023 | |
| CYP321A16 | Spodoptera exigua | chlorpyrifos | Hu et al., 2020 | |
| CYP321A19 | Spodoptera litura | indoxacarb,chlorantraniliprole,λ-cyhalothrin,imidacloprid NOT chlorpyrifos | Li et al., 2023 | |
| CYP321B1 | Spodoptera exigua | chlorpyriphos, cypermethrin, deltamethrin | Hu et al., 2025 | |
| CYP321F3 | Chilo suppressalis | methoxyfenozide | Guo et al., 2025 | |
| CYP324A12 | Chilo suppressalis | lethality at 2nd larval instar | Guo et al., 2025 | |
| CYP332A1 | Spodoptera exigua | chlorpyrifos | Hu et al., 2020 | |
| CYP332A1 | Spodoptera litura | cyantraniliprole (by feeding, not topical) | Li et al., 2023 | |
| CYP337B3 | Helicoverpa armigera | fenvalerate | cited in McLeman et al., 2020 | |
| CYP402C1 | Bemisia tabaci | imidacloprid | Guo et al., 2022 | |
| CYP4 clan | ||||
| CYP4C61 | Nilaparvata lugens | dinotefuran,thiamethoxam,nitenpyram | Zhang et al., 2023 | |
| CYP4D24 | Aedes aegypti | permethrin | Reid et al., 2014 | |
| CYP4H29 | Aedes aegypti | permethrin | Reid et al., 2014 | |
| CYP4H33 | Aedes aegypti | permethrin | Reid et al., 2014 | |
| CYP4J15v1 | Aedes aegypti | permethrin | Reid et al., 2014 | |
| CYP4S9 | Spodoptera litura | abamectin | Liang et al., 2024 | |
| CYP4S24 | Musca domestica | permethrin | Li et al., 2023 | |
| CYP4CJ1 | Aphis gossypii | cyantraniliprole | Zeng et al. 2021 | |
| CYP4CJ2 | Aphis gossypii | cycloxaprid | Dong et al. 2025 | |
| CYP4CK1 | Aphis gossypii | thiamethoxam | Lv et al. 2022 | |
| CYP4CK1 | Aphis gossypii | cyantraniliprole | Ding et al. 2023 | |
| CYP4CL2 | Panonychus citri | pyridaben | Pan et al., 2023 | |
| CYP4CS5 | Bemisia tabaci | thiamethoxam, clothianidin | Hu et al., 2024 | |
| CYP4FB1 | Laodelphax striatellus | deltamethrin, fenvalerate, etofenprox | Yu et al., 2023 | |
| CYP340G2 | Spodoptera litura | indoxacarb,chlorantraniliprole,λ-cyhalothrin,imidacloprid NOT chlorpyrifos,λ-cyhalothrin | Li et al., 2023 | |
| CYP380C6 | Aphis gossypii | spirotetramat | Pan et al. 2018 | |
| CYP380C6 | Aphis gossypii | cyantraniliprole, a-cypermethrin | Zeng et al. 2021 | |
| CYP380C40 | Myzus persicae | sulfoxaflor | Pym et al., 2022 | |
| CYP340L25 (called 340L) | Spodoptera litura | no effect on cyantraniliprole tox | Li et al., 2023 | |
| CYP340AX8 (called 340A) | Spodoptera litura | cyantraniliprole | Li et al., 2023 | |
| CYP439A1 | Laodelphax striatellus | NOT fenvalerate | Yu et al., 2023 | |
| Mito clan | ||||
| CYP12A4 | Drosophila melanogaster | (OE) lufenuron | Bogwitz et al., 2005 | |
| CYP12A5 | Drosophila melanogaster | (OE) nitenpyram (activation) | Harrop et al. 2018 | |
| CYP12D1 | Drosophila melanogaster | (OE) DDT, dicyclanil | Daborn et al. 2007 | |
| CYP12D1 | Drosophila melanogaster | (OE) malathion | Battlay et al. 2018 | |
| CYP301B1 | Laodelphax striatellus | deltamethrin, fenvalerate, etofenprox | Yu et al., 2023 | |
| CYP302A1 | Nilaparvata lugens | dinotefuran,thiamethoxam,nitenpyram | Zhang et al., 2023 | |
| CYP314A1 | Nilaparvata lugens | dinotefuran,imidacloprid,thiamethoxam,nitenpyram | Zhang et al., 2023 | |
| CYP333A29 | Hyphantria cunea | β-cypermethrin | Niu et al.,2025 | |
| CYP339A1 | Spodoptera litura | indoxacarb,chlorantraniliprole,λ-cyhalothrin,imidacloprid NOT chlorpyrifos | Li et al., 2023 | |
| CYP419A1 | Nilaparvata lugens | ethiprole | Zeng et al., 2025 | |
transgenic_expression.txt · Last modified: by renefeyereisen